INHBB

GENE INFORMATION

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Gene name

INHBB

Synonyms

Description

Inhibin, beta B (HGNC Symbol)

Entrez gene summary

The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q14.2

Chromosome location (bp)

120346143 - 120351808

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163083 (version 78.38)

Entrez gene

3625

UniProt

P09529 (UniProt - Evidence at protein level)

neXtProt

NX_P09529

Antibodypedia

INHBB antibodies
 

PROTEIN VIEW

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INHBB-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

INHBB-001 ENSP00000295228
ENST00000295228
P09529
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