GRIN2C

GENE INFORMATION

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Gene name

GRIN2C (HGNC Symbol)

Synonyms

GluN2C, NMDAR2C

Description

Glutamate receptor, ionotropic, N-methyl D-aspartate 2C (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Chromosome

17

Cytoband

q25.1

Chromosome location (bp)

74842023 - 74861504

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000161509 (version 78.38)

Entrez gene

2905

UniProt

Q14957 (UniProt - Evidence at protein level)

neXtProt

NX_Q14957

Antibodypedia

GRIN2C antibodies
 

PROTEIN VIEW

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GRIN2C-001
 
GRIN2C-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRIN2C-001 ENSP00000293190
ENST00000293190
Q14957
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Show » Show » 1233 134.2 Yes 4
GRIN2C-002 ENSP00000338645
ENST00000347612
H0Y2V8
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Show » Show » 873 96 Yes 4