TONSL

GENE INFORMATION

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Gene name

TONSL (HGNC Symbol)

Synonyms

IKBR, NFKBIL2

Description

Tonsoku-like, DNA repair protein (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

q24.3

Chromosome location (bp)

144428775 - 144444444

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160949 (version 78.38)

Entrez gene

4796

UniProt

Q96HA7 (UniProt - Evidence at protein level)

neXtProt

NX_Q96HA7

Antibodypedia

TONSL antibodies
 

PROTEIN VIEW

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TONSL-001
 
TONSL-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TONSL-001 ENSP00000386239
ENST00000409379
Q96HA7
Show all »
Show » Show » 1378 150.9 No 0
TONSL-201 ENSP00000484162
ENST00000613741
Show » Show » 477 52.1 No 0