Tissue expression of ITGB2 - Summary - The Human Protein Atlas

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ITGB2

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	ITGB2
Gene description	Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Protein class	CD markers Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	16
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic and membranous expression in subsets of cells in lymphoid tissue and bone marrow.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Supportive based on 2 antibodies. HPA008877 , HPA016894
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	ITGB2 (HGNC Symbol)
Synonyms	CD18, LFA-1, MAC-1, MFI7
Description	Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (HGNC Symbol)
Entrez gene summary	This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	44885953 - 44931989
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160255 (version 78.38)
Entrez gene	3689
UniProt	P05107 (UniProt - Evidence at protein level)
neXtProt	NX_P05107
Antibodypedia	ITGB2 antibodies

PROTEIN BROWSER

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ENST00000302347		ENST00000320216		ENST00000355153		ENST00000397846		ENST00000397850		ENST00000397852		ENST00000397854		ENST00000397857		ENST00000517563		ENST00000517819		ENST00000521995		ENST00000522688		ENST00000522931		ENST00000523663		ENST00000524251		ENST00000610622

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
ITGB2-001	ENSP00000347279 ENST00000355153	P05107 Show all » « Hide P05107 [Direct mapping] Integrin beta-2 B4E0R1 [Target identity:91%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E7EVZ9 [Target identity:21%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RK25 [Target identity:20%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RIG7 [Target identity:15%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} A0A024DBF0 [Target identity:10%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RFI0 [Target identity:9%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} A0A024DAT2 [Target identity:9%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44437.1} A0A024DAF4 [Target identity:9%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44433.1} A0A024DBG3 [Target identity:8%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44435.1} Q96PT7 [Target identity:7%; Query identity:100%] Integrin beta 2 {ECO:0000313\|EMBL:AAL14027.1}; Integrin beta-2 {ECO:0000313\|EMBL:AHZ44417.1} A0A024D9P8 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44431.1} E5RHT0 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44414.1, ECO:0000313\|Ensembl:ENSP00000429683} E5RK54 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000428125} A0A024DAS5 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44427.1} E5RHE6 [Target identity:4%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000430901} A0A024DBF8 [Target identity:3%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44430.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001948 [glycoprotein binding] GO:0002224 [toll-like receptor signaling pathway] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007159 [leukocyte cell-cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007267 [cell-cell signaling] GO:0007275 [multicellular organismal development] GO:0007596 [blood coagulation] GO:0008305 [integrin complex] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0030198 [extracellular matrix organization] GO:0030369 [ICAM-3 receptor activity] GO:0030593 [neutrophil chemotaxis] GO:0031982 [vesicle] GO:0034113 [heterotypic cell-cell adhesion] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034687 [integrin alphaL-beta2 complex] GO:0035987 [endodermal cell differentiation] GO:0043113 [receptor clustering] GO:0043235 [receptor complex] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0050900 [leukocyte migration] GO:0070062 [extracellular vesicular exosome]	769	84.8	Yes	1
ITGB2-002	ENSP00000380948 ENST00000397850	P05107 Show all » « Hide P05107 [Direct mapping] Integrin beta-2 B4E0R1 [Target identity:91%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E7EVZ9 [Target identity:21%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RK25 [Target identity:20%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RIG7 [Target identity:15%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} A0A024DBF0 [Target identity:10%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RFI0 [Target identity:9%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} A0A024DAT2 [Target identity:9%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44437.1} A0A024DAF4 [Target identity:9%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44433.1} A0A024DBG3 [Target identity:8%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44435.1} Q96PT7 [Target identity:7%; Query identity:100%] Integrin beta 2 {ECO:0000313\|EMBL:AAL14027.1}; Integrin beta-2 {ECO:0000313\|EMBL:AHZ44417.1} A0A024D9P8 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44431.1} E5RHT0 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44414.1, ECO:0000313\|Ensembl:ENSP00000429683} E5RK54 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000428125} A0A024DAS5 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44427.1} E5RHE6 [Target identity:4%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000430901} A0A024DBF8 [Target identity:3%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44430.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001948 [glycoprotein binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002523 [leukocyte migration involved in inflammatory response] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007159 [leukocyte cell-cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007267 [cell-cell signaling] GO:0007275 [multicellular organismal development] GO:0007568 [aging] GO:0007596 [blood coagulation] GO:0008305 [integrin complex] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0019901 [protein kinase binding] GO:0030101 [natural killer cell activation] GO:0030198 [extracellular matrix organization] GO:0030369 [ICAM-3 receptor activity] GO:0030593 [neutrophil chemotaxis] GO:0031982 [vesicle] GO:0032403 [protein complex binding] GO:0034113 [heterotypic cell-cell adhesion] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034687 [integrin alphaL-beta2 complex] GO:0035987 [endodermal cell differentiation] GO:0043113 [receptor clustering] GO:0043235 [receptor complex] GO:0043542 [endothelial cell migration] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045123 [cellular extravasation] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050776 [regulation of immune response] GO:0050798 [activated T cell proliferation] GO:0050839 [cell adhesion molecule binding] GO:0050900 [leukocyte migration] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0070062 [extracellular vesicular exosome]	769	84.8	Yes	1
ITGB2-003	ENSP00000380952 ENST00000397854	D3DSM0 Show all » « Hide D3DSM0 [Target identity:100%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} A0A024DBF0 [Target identity:11%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} A0A024DAF4 [Target identity:10%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44433.1} A0A024DAT2 [Target identity:10%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44437.1} A0A024DBG3 [Target identity:9%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44435.1} E5RFI0 [Target identity:9%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} A0A024DAS5 [Target identity:7%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44427.1} A0A024D9P8 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44431.1} E5RHT0 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44414.1, ECO:0000313\|Ensembl:ENSP00000429683} E5RHE6 [Target identity:5%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000430901} A0A024DBF8 [Target identity:4%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44430.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007275 [multicellular organismal development] GO:0008305 [integrin complex] GO:0016020 [membrane]	712	78.4	Yes	1
ITGB2-004	ENSP00000380955 ENST00000397857	P05107 Show all » « Hide P05107 [Direct mapping] Integrin beta-2 B4E0R1 [Target identity:91%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E7EVZ9 [Target identity:21%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RK25 [Target identity:20%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RIG7 [Target identity:15%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} A0A024DBF0 [Target identity:10%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RFI0 [Target identity:9%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} A0A024DAT2 [Target identity:9%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44437.1} A0A024DAF4 [Target identity:9%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44433.1} A0A024DBG3 [Target identity:8%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44435.1} Q96PT7 [Target identity:7%; Query identity:100%] Integrin beta 2 {ECO:0000313\|EMBL:AAL14027.1}; Integrin beta-2 {ECO:0000313\|EMBL:AHZ44417.1} A0A024D9P8 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44431.1} E5RHT0 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44414.1, ECO:0000313\|Ensembl:ENSP00000429683} E5RK54 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000428125} A0A024DAS5 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44427.1} E5RHE6 [Target identity:4%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000430901} A0A024DBF8 [Target identity:3%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44430.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001948 [glycoprotein binding] GO:0002224 [toll-like receptor signaling pathway] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007159 [leukocyte cell-cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007267 [cell-cell signaling] GO:0007275 [multicellular organismal development] GO:0007596 [blood coagulation] GO:0008305 [integrin complex] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0030198 [extracellular matrix organization] GO:0030369 [ICAM-3 receptor activity] GO:0030593 [neutrophil chemotaxis] GO:0031982 [vesicle] GO:0034113 [heterotypic cell-cell adhesion] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034687 [integrin alphaL-beta2 complex] GO:0035987 [endodermal cell differentiation] GO:0043113 [receptor clustering] GO:0043235 [receptor complex] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0050900 [leukocyte migration] GO:0070062 [extracellular vesicular exosome]	769	84.8	Yes	1
ITGB2-005	ENSP00000380950 ENST00000397852	P05107 Show all » « Hide P05107 [Direct mapping] Integrin beta-2 B4E0R1 [Target identity:91%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E7EVZ9 [Target identity:21%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RK25 [Target identity:20%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RIG7 [Target identity:15%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} A0A024DBF0 [Target identity:10%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RFI0 [Target identity:9%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} A0A024DAT2 [Target identity:9%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44437.1} A0A024DAF4 [Target identity:9%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44433.1} A0A024DBG3 [Target identity:8%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44435.1} Q96PT7 [Target identity:7%; Query identity:100%] Integrin beta 2 {ECO:0000313\|EMBL:AAL14027.1}; Integrin beta-2 {ECO:0000313\|EMBL:AHZ44417.1} A0A024D9P8 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44431.1} E5RHT0 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44414.1, ECO:0000313\|Ensembl:ENSP00000429683} E5RK54 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000428125} A0A024DAS5 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44427.1} E5RHE6 [Target identity:4%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000430901} A0A024DBF8 [Target identity:3%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44430.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001948 [glycoprotein binding] GO:0002224 [toll-like receptor signaling pathway] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007159 [leukocyte cell-cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007267 [cell-cell signaling] GO:0007275 [multicellular organismal development] GO:0007596 [blood coagulation] GO:0008305 [integrin complex] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0030198 [extracellular matrix organization] GO:0030369 [ICAM-3 receptor activity] GO:0030593 [neutrophil chemotaxis] GO:0031982 [vesicle] GO:0034113 [heterotypic cell-cell adhesion] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034687 [integrin alphaL-beta2 complex] GO:0035987 [endodermal cell differentiation] GO:0043113 [receptor clustering] GO:0043235 [receptor complex] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0050900 [leukocyte migration] GO:0070062 [extracellular vesicular exosome]	769	84.8	Yes	1
ITGB2-008	ENSP00000380944 ENST00000397846	A8MVG7 Show all » « Hide A8MVG7 [Target identity:100%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000380944} E5RHT0 [Target identity:45%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44414.1, ECO:0000313\|Ensembl:ENSP00000429683}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007275 [multicellular organismal development] GO:0008305 [integrin complex] GO:0016020 [membrane]	108	11.4	Yes	0
ITGB2-010	ENSP00000317697 ENST00000320216	J3KNI6 Show all » « Hide J3KNI6 [Target identity:100%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} A0A024DBF0 [Target identity:24%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} Q96PT7 [Target identity:17%; Query identity:100%] Integrin beta 2 {ECO:0000313\|EMBL:AAL14027.1}; Integrin beta-2 {ECO:0000313\|EMBL:AHZ44417.1} A0A024DAS5 [Target identity:16%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44427.1} E5RK54 [Target identity:15%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000428125} E5RHE6 [Target identity:11%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000430901}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007275 [multicellular organismal development] GO:0008305 [integrin complex] GO:0016020 [membrane]	322	35.7	No	0
ITGB2-014	ENSP00000429683 ENST00000521995	E5RHT0 Show all » « Hide E5RHT0 [Target identity:100%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44414.1, ECO:0000313\|Ensembl:ENSP00000429683}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007275 [multicellular organismal development] GO:0008305 [integrin complex] GO:0016020 [membrane]	49	5.3	Yes	0
ITGB2-015	ENSP00000428413 ENST00000517563	E5RIG7 Show all » « Hide E5RIG7 [Target identity:100%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RFI0 [Target identity:58%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RHT0 [Target identity:40%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44414.1, ECO:0000313\|Ensembl:ENSP00000429683} E5RK54 [Target identity:40%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000428125} E5RHE6 [Target identity:30%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000430901}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007275 [multicellular organismal development] GO:0008305 [integrin complex] GO:0016020 [membrane]	120	13	Yes	0
ITGB2-016	ENSP00000428870 ENST00000517819	E5RFI0 Show all » « Hide E5RFI0 [Target identity:100%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RHT0 [Target identity:70%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44414.1, ECO:0000313\|Ensembl:ENSP00000429683}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007275 [multicellular organismal development] GO:0008305 [integrin complex] GO:0016020 [membrane]	70	7.6	Yes	0
ITGB2-017	ENSP00000428125 ENST00000522688	E5RK54 Show all » « Hide E5RK54 [Target identity:100%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000428125} E5RHE6 [Target identity:75%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000430901}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008305 [integrin complex]	49	5.3	No	0
ITGB2-021	ENSP00000430901 ENST00000524251	E5RHE6 Show all » « Hide E5RHE6 [Target identity:100%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000430901}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		37	4	No	0
ITGB2-022	ENSP00000428979 ENST00000522931	E5RK25 Show all » « Hide E5RK25 [Target identity:100%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RIG7 [Target identity:75%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RFI0 [Target identity:43%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RHT0 [Target identity:30%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44414.1, ECO:0000313\|Ensembl:ENSP00000429683} E5RK54 [Target identity:30%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000428125} E5RHE6 [Target identity:23%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000430901}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007275 [multicellular organismal development] GO:0008305 [integrin complex] GO:0016020 [membrane]	160	17.6	Yes	0
ITGB2-024	ENSP00000428503 ENST00000523663	E7EVZ9 Show all » « Hide E7EVZ9 [Target identity:100%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RK25 [Target identity:96%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RIG7 [Target identity:72%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RFI0 [Target identity:42%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} Q96PT7 [Target identity:33%; Query identity:100%] Integrin beta 2 {ECO:0000313\|EMBL:AAL14027.1}; Integrin beta-2 {ECO:0000313\|EMBL:AHZ44417.1} E5RHT0 [Target identity:29%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44414.1, ECO:0000313\|Ensembl:ENSP00000429683} E5RK54 [Target identity:29%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000428125} E5RHE6 [Target identity:22%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000430901}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007275 [multicellular organismal development] GO:0008305 [integrin complex] GO:0016020 [membrane]	166	18.3	Yes	0
ITGB2-201	ENSP00000303242 ENST00000302347	P05107 Show all » « Hide P05107 [Direct mapping] Integrin beta-2 B4E0R1 [Target identity:91%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E7EVZ9 [Target identity:21%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RK25 [Target identity:20%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RIG7 [Target identity:15%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} A0A024DBF0 [Target identity:10%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RFI0 [Target identity:9%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} A0A024DAT2 [Target identity:9%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44437.1} A0A024DAF4 [Target identity:9%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44433.1} A0A024DBG3 [Target identity:8%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44435.1} Q96PT7 [Target identity:7%; Query identity:100%] Integrin beta 2 {ECO:0000313\|EMBL:AAL14027.1}; Integrin beta-2 {ECO:0000313\|EMBL:AHZ44417.1} A0A024D9P8 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44431.1} E5RHT0 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44414.1, ECO:0000313\|Ensembl:ENSP00000429683} E5RK54 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000428125} A0A024DAS5 [Target identity:6%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44427.1} E5RHE6 [Target identity:4%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000430901} A0A024DBF8 [Target identity:3%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44430.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001948 [glycoprotein binding] GO:0002224 [toll-like receptor signaling pathway] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007159 [leukocyte cell-cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007267 [cell-cell signaling] GO:0007275 [multicellular organismal development] GO:0007596 [blood coagulation] GO:0008305 [integrin complex] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0030198 [extracellular matrix organization] GO:0030369 [ICAM-3 receptor activity] GO:0030593 [neutrophil chemotaxis] GO:0031982 [vesicle] GO:0034113 [heterotypic cell-cell adhesion] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034687 [integrin alphaL-beta2 complex] GO:0035987 [endodermal cell differentiation] GO:0043113 [receptor clustering] GO:0043235 [receptor complex] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0050900 [leukocyte migration] GO:0070062 [extracellular vesicular exosome]	769	84.8	Yes	1
ITGB2-202	ENSP00000480700 ENST00000610622	A0A024DBF0 Show all » « Hide A0A024DBF0 [Target identity:21%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} E5RFI0 [Target identity:18%; Query identity:100%] Integrin beta {ECO:0000256\|RuleBase:RU000633} A0A024DAS5 [Target identity:13%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44427.1} A0A024D9P8 [Target identity:12%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44431.1} E5RHT0 [Target identity:12%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44414.1, ECO:0000313\|Ensembl:ENSP00000429683} E5RHE6 [Target identity:9%; Query identity:100%] Integrin beta-2 {ECO:0000313\|Ensembl:ENSP00000430901} A0A024DBF8 [Target identity:7%; Query identity:100%] Integrin beta-2 {ECO:0000313\|EMBL:AHZ44430.1}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007275 [multicellular organismal development] GO:0008305 [integrin complex] GO:0016020 [membrane]	378	41.7	Yes	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx