G6PD - Gene info - The Human Protein Atlas

Gene name

G6PD (HGNC Symbol)

Synonyms

G6PD1

Description

Glucose-6-phosphate dehydrogenase (HGNC Symbol)

Entrez gene summary

This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q28

Chromosome location (bp)

154531391 - 154547572

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160211 (version 78.38)

Entrez gene

2539

UniProt

P11413 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

G6PD-001

ENSP00000377192
ENST00000393562

P11413
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P11413 [Direct mapping]
Glucose-6-phosphate 1-dehydrogenase
Q2VF42 [Target identity:87%; Query identity:100%]
Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU000497}
E9PD92 [Target identity:46%; Query identity:100%]
Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU000497}
A2IBT6 [Target identity:9%; Query identity:100%]
Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU000497}

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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001816 [cytokine production]
GO:0004345 [glucose-6-phosphate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005536 [glucose binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006098 [pentose-phosphate shunt]
GO:0006629 [lipid metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006739 [NADP metabolic process]
GO:0006740 [NADPH regeneration]
GO:0006749 [glutathione metabolic process]
GO:0009051 [pentose-phosphate shunt, oxidative branch]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010734 [negative regulation of protein glutathionylation]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0019322 [pentose biosynthetic process]
GO:0021762 [substantia nigra development]
GO:0030246 [carbohydrate binding]
GO:0032094 [response to food]
GO:0034599 [cellular response to oxidative stress]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043249 [erythrocyte maturation]
GO:0043523 [regulation of neuron apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0046390 [ribose phosphate biosynthetic process]
GO:0050661 [NADP binding]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular vesicular exosome]

545

62.5

G6PD-002

ENSP00000395599
ENST00000439227

E7EUI8
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E7EUI8 [Target identity:99%; Query identity:100%]
Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU000497}
E7EM57 [Target identity:94%; Query identity:100%]
Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU000497}
A2IBT6 [Target identity:15%; Query identity:100%]
Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU000497}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004345 [glucose-6-phosphate dehydrogenase activity]
GO:0006006 [glucose metabolic process]
GO:0006098 [pentose-phosphate shunt]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]

339

38.5

G6PD-005

ENSP00000394690
ENST00000433845

E9PD92
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E9PD92 [Target identity:100%; Query identity:100%]
Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU000497}
A2IBT6 [Target identity:19%; Query identity:100%]
Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU000497}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004345 [glucose-6-phosphate dehydrogenase activity]
GO:0006006 [glucose metabolic process]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]

256

29.5

G6PD-006

ENSP00000377194
ENST00000393564

P11413
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P11413 [Direct mapping]
Glucose-6-phosphate 1-dehydrogenase
Q2VF42 [Target identity:92%; Query identity:100%]
Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU000497}
E9PD92 [Target identity:49%; Query identity:100%]
Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU000497}
A2IBT6 [Target identity:9%; Query identity:100%]
Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU000497}

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GO:0001816 [cytokine production]
GO:0004345 [glucose-6-phosphate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005536 [glucose binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006098 [pentose-phosphate shunt]
GO:0006629 [lipid metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006739 [NADP metabolic process]
GO:0006740 [NADPH regeneration]
GO:0006749 [glutathione metabolic process]
GO:0009051 [pentose-phosphate shunt, oxidative branch]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010734 [negative regulation of protein glutathionylation]
GO:0016020 [membrane]
GO:0019322 [pentose biosynthetic process]
GO:0021762 [substantia nigra development]
GO:0034599 [cellular response to oxidative stress]
GO:0042803 [protein homodimerization activity]
GO:0043249 [erythrocyte maturation]
GO:0044281 [small molecule metabolic process]
GO:0046390 [ribose phosphate biosynthetic process]
GO:0050661 [NADP binding]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular vesicular exosome]

515

59.3

G6PD-007

ENSP00000400648
ENST00000440967

E7EM57
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E7EM57 [Target identity:100%; Query identity:100%]
Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU000497}
A2IBT6 [Target identity:15%; Query identity:100%]
Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU000497}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0004345 [glucose-6-phosphate dehydrogenase activity]
GO:0006006 [glucose metabolic process]
GO:0006098 [pentose-phosphate shunt]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]

320

36.5

G6PD-010

ENSP00000358633
ENST00000369620

P11413
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P11413 [Direct mapping]
Glucose-6-phosphate 1-dehydrogenase
E9PD92 [Target identity:45%; Query identity:100%]
Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU000497}
A2IBT6 [Target identity:9%; Query identity:100%]
Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU000497}

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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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561

63.8

G6PD-201

ENSP00000483686
ENST00000621232

P11413
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515

59.3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.