TMPRSS3

GENERAL INFORMATION

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Gene name

TMPRSS3

Gene description

Transmembrane protease, serine 3

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (fallopian tube, stomach)
GTEx:Tissue enhanced (salivary gland)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (fallopian tube, stomach)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (salivary gland)

Organ

Expression



GENE INFORMATION

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Gene name

TMPRSS3 (HGNC Symbol)

Synonyms

DFNB10, DFNB8

Description

Transmembrane protease, serine 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

Chromosome

21

Cytoband

q22.3

Chromosome location (bp)

42371890 - 42396846

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160183 (version 78.38)

Entrez gene

64699

UniProt

P57727 (UniProt - Evidence at protein level)

neXtProt

NX_P57727

Antibodypedia

TMPRSS3 antibodies


PROTEIN BROWSER

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ENST00000291532
 
ENST00000398397
 
ENST00000398405
 
ENST00000433957
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TMPRSS3-001 ENSP00000291532
ENST00000291532
P57727
Show all »
Show » Show » 454 49.4 No 1
TMPRSS3-002 ENSP00000411013
ENST00000433957
P57727
Show all »
Show » Show » 453 49.3 No 1
TMPRSS3-003 ENSP00000381434
ENST00000398397
P57727
Show all »
Show » Show » 344 37.5 No 1
TMPRSS3-004 ENSP00000381442
ENST00000398405
B7WPR2
Show all »
Show » Show » 451 49.1 No 1