ARHGAP35

GENE INFORMATION

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Gene name

ARHGAP35 (HGNC Symbol)

Synonyms

GRF-1, GRLF1, KIAA1722, P190A, p190ARhoGAP, p190RhoGAP

Description

Rho GTPase activating protein 35 (HGNC Symbol)

Entrez gene summary

The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.32

Chromosome location (bp)

46918676 - 47005077

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160007 (version 78.38)

Entrez gene

2909

UniProt

Q9NRY4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NRY4

Antibodypedia

ARHGAP35 antibodies
 

PROTEIN VIEW

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ARHGAP35-001
 
ARHGAP35-201
 
ARHGAP35-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARHGAP35-001 ENSP00000385720
ENST00000404338
Q9NRY4
Show all »
Show » Show » 1499 170.5 No 0
ARHGAP35-201 ENSP00000483730
ENST00000614079
Q9NRY4
Show all »
Show » Show » 1499 170.5 No 0
ARHGAP35-202 ENSP00000479487
ENST00000615647
A2RRE5
Show all »
Show » Show » 749 86.3 No 0