TNFRSF13C

GENE INFORMATION

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Gene name

TNFRSF13C (HGNC Symbol)

Synonyms

BAFFR, CD268

Description

Tumor necrosis factor receptor superfamily, member 13C (HGNC Symbol)

Entrez gene summary

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q13.2

Chromosome location (bp)

41925041 - 41926818

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159958 (version 78.38)

Entrez gene

115650

UniProt

Q96RJ3 (UniProt - Evidence at protein level)

neXtProt

NX_Q96RJ3

Antibodypedia

TNFRSF13C antibodies
 

PROTEIN VIEW

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TNFRSF13C-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNFRSF13C-001 ENSP00000291232
ENST00000291232
Q96RJ3
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