CTBP1 - Gene info - The Human Protein Atlas

Gene name

CTBP1 (HGNC Symbol)

Synonyms

BARS

Description

C-terminal binding protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

p16.3

Chromosome location (bp)

1211448 - 1249953

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159692 (version 78.38)

Entrez gene

1487

UniProt

Q13363 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTBP1-001

ENSP00000290921
ENST00000290921

Q13363
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Q13363 [Direct mapping]
C-terminal-binding protein 1
X5D8Y5 [Target identity:100%; Query identity:100%]
C-terminal binding protein 1 isoform C {ECO:0000313|EMBL:AHW56458.1}

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SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0004616 [phosphogluconate dehydrogenase (decarboxylating) activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005829 [cytosol]
GO:0006098 [pentose-phosphate shunt]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007030 [Golgi organization]
GO:0008022 [protein C-terminus binding]
GO:0008134 [transcription factor binding]
GO:0008152 [metabolic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0017053 [transcriptional repressor complex]
GO:0019079 [viral genome replication]
GO:0019904 [protein domain specific binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0034401 [regulation of transcription by chromatin organization]
GO:0035067 [negative regulation of histone acetylation]
GO:0042803 [protein homodimerization activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0050872 [white fat cell differentiation]
GO:0051287 [NAD binding]
GO:0051726 [regulation of cell cycle]
GO:0055114 [oxidation-reduction process]
GO:0070491 [repressing transcription factor binding]
GO:0090241 [negative regulation of histone H4 acetylation]

440

47.5

CTBP1-002

ENSP00000420983
ENST00000513420

E9PGB1
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E9PGB1 [Target identity:100%; Query identity:100%]
C-terminal-binding protein 1 {ECO:0000313|Ensembl:ENSP00000420983}
Q9NSY3 [Target identity:37%; Query identity:100%]
Putative uncharacterized protein DKFZp434B0914 {ECO:0000313|EMBL:CAB70861.2}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0008152 [metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]

145

15.9

CTBP1-003

ENSP00000372411
ENST00000382952

Q13363
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Q13363 [Direct mapping]
C-terminal-binding protein 1
E7ESU7 [Target identity:39%; Query identity:100%]
C-terminal-binding protein 1 {ECO:0000313|Ensembl:ENSP00000425053}
E9PGB1 [Target identity:33%; Query identity:100%]
C-terminal-binding protein 1 {ECO:0000313|Ensembl:ENSP00000420983}
Q9NSY3 [Target identity:12%; Query identity:100%]
Putative uncharacterized protein DKFZp434B0914 {ECO:0000313|EMBL:CAB70861.2}

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SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0004616 [phosphogluconate dehydrogenase (decarboxylating) activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006098 [pentose-phosphate shunt]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0008022 [protein C-terminus binding]
GO:0008134 [transcription factor binding]
GO:0008152 [metabolic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0017053 [transcriptional repressor complex]
GO:0019079 [viral genome replication]
GO:0019904 [protein domain specific binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0034401 [regulation of transcription by chromatin organization]
GO:0035067 [negative regulation of histone acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0050872 [white fat cell differentiation]
GO:0051287 [NAD binding]
GO:0051726 [regulation of cell cycle]
GO:0055114 [oxidation-reduction process]
GO:0070491 [repressing transcription factor binding]
GO:0090241 [negative regulation of histone H4 acetylation]

429

46.4

CTBP1-005

ENSP00000424684
ENST00000506180

D6RAX2
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D6RAX2 [Target identity:99%; Query identity:100%]
C-terminal-binding protein 1 {ECO:0000313|Ensembl:ENSP00000424684}

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SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0008152 [metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]

187

20.3

CTBP1-006

ENSP00000425053
ENST00000515399

E7ESU7
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E7ESU7 [Target identity:100%; Query identity:100%]
C-terminal-binding protein 1 {ECO:0000313|Ensembl:ENSP00000425053}
E9PGB1 [Target identity:84%; Query identity:100%]
C-terminal-binding protein 1 {ECO:0000313|Ensembl:ENSP00000420983}
Q9NSY3 [Target identity:32%; Query identity:100%]
Putative uncharacterized protein DKFZp434B0914 {ECO:0000313|EMBL:CAB70861.2}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0008152 [metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]

171

18.6

CTBP1-008

ENSP00000423872
ENST00000510568

E7EUB3
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E7EUB3 [Target identity:100%; Query identity:100%]
C-terminal-binding protein 1 {ECO:0000313|Ensembl:ENSP00000423872}
Q9NSY3 [Target identity:32%; Query identity:100%]
Putative uncharacterized protein DKFZp434B0914 {ECO:0000313|EMBL:CAB70861.2}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

168

18.1

CTBP1-010

ENSP00000422364
ENST00000504092

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0008152 [metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]

287

30.9

CTBP1-013

ENSP00000426470
ENST00000514210

E7EPF8
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E7EPF8 [Target identity:100%; Query identity:100%]
C-terminal-binding protein 1 {ECO:0000313|Ensembl:ENSP00000426470}
E7ESU7 [Target identity:84%; Query identity:100%]
C-terminal-binding protein 1 {ECO:0000313|Ensembl:ENSP00000425053}
E9PGB1 [Target identity:71%; Query identity:100%]
C-terminal-binding protein 1 {ECO:0000313|Ensembl:ENSP00000420983}
Q9NSY3 [Target identity:27%; Query identity:100%]
Putative uncharacterized protein DKFZp434B0914 {ECO:0000313|EMBL:CAB70861.2}

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MEMSAT3 predicted membrane proteins
SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0008152 [metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]

202

21.6

CTBP1-015

ENSP00000422148
ENST00000503594

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]

184

19.4

CTBP1-017

ENSP00000422730
ENST00000504784

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

2.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.