B4GALT3

GENE INFORMATION

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Gene name

B4GALT3 (HGNC Symbol)

Synonyms

beta4Gal-T3

Description

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 (HGNC Symbol)

Entrez gene summary

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]

Chromosome

1

Cytoband

q23.3

Chromosome location (bp)

161171310 - 161177968

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158850 (version 78.38)

Entrez gene

8703

UniProt

O60512 (UniProt - Evidence at protein level)

neXtProt

NX_O60512

Antibodypedia

B4GALT3 antibodies
 

PROTEIN VIEW

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B4GALT3-001
 
B4GALT3-002
 
B4GALT3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

B4GALT3-001 ENSP00000320965
ENST00000319769
O60512
Show all »
Show » Show » 393 43.9 No 0
B4GALT3-002 ENSP00000356977
ENST00000367998
O60512
Show all »
Show » Show » 393 43.9 No 0
B4GALT3-201 ENSP00000480428
ENST00000622395
O60512
Show all »
Show » Show » 393 43.9 No 0