CACNA2D3

GENE INFORMATION

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Gene name

CACNA2D3 (HGNC Symbol)

Synonyms

HSA272268

Description

Calcium channel, voltage-dependent, alpha 2/delta subunit 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

Chromosome location (bp)

54122547 - 55074557

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000157445 (version 78.38)

Entrez gene

55799

UniProt

Q8IZS8 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IZS8

Antibodypedia

CACNA2D3 antibodies
 

PROTEIN VIEW

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CACNA2D3-001
 
CACNA2D3-002
 
CACNA2D3-006
 
CACNA2D3-201
 
CACNA2D3-202
 
CACNA2D3-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CACNA2D3-001 ENSP00000419101
ENST00000474759
Q8IZS8
Show all »
Show » Show » 1091 123 Yes 2
CACNA2D3-002 ENSP00000417279
ENST00000490478
Q8IZS8
Show all »
Show » Show » 997 113 No 2
CACNA2D3-006 ENSP00000418028
ENST00000492460
C9JAV5
Show all »
Show » 126 14.6 No 0
CACNA2D3-201 ENSP00000288197
ENST00000288197
Q8IZS8
Show all »
Show » Show » 1091 123 Yes 2
CACNA2D3-202 ENSP00000389506
ENST00000415676
Q8IZS8
Show all »
Show » Show » 1091 123 Yes 2
CACNA2D3-203 ENSP00000478969
ENST00000620722
Q8IZS8
Show all »
Show » Show » 519 59.5 No 0