CLDN12

GENE INFORMATION

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Gene name

CLDN12

Synonyms

Description

Claudin 12 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011]

Chromosome

7

Cytoband

q21.13

Chromosome location (bp)

90383721 - 90513402

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000157224 (version 78.38)

Entrez gene

9069

UniProt

P56749 (UniProt - Evidence at protein level)

neXtProt

NX_P56749

Antibodypedia

CLDN12 antibodies
 

PROTEIN VIEW

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CLDN12-001
 
CLDN12-002
 
CLDN12-005
 
CLDN12-013
 
CLDN12-015
 
CLDN12-016
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLDN12-001 ENSP00000287916
ENST00000287916
P56749
Show all »
Show » Show » 244 27.1 No 4
CLDN12-002 ENSP00000378103
ENST00000394605
P56749
Show all »
Show » Show » 244 27.1 No 4
CLDN12-005 ENSP00000391062
ENST00000427904
C9J4P0
Show all »
Show » Show » 126 13.9 No 2
CLDN12-013 ENSP00000378102
ENST00000394604
A8MX62
Show all »
Show » Show » 187 20.6 No 3
CLDN12-015 ENSP00000411399
ENST00000416322
C9J841
Show all »
Show » Show » 175 19.4 No 3
CLDN12-016 ENSP00000419053
ENST00000496677
P56749
Show all »
Show » Show » 244 27.1 No 4