BACH1 - Gene info - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. Don't show this again.

BACH1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

? »

Gene name	BACH1 (HGNC Symbol)
Synonyms	BACH-1, BTBD24
Description	BTB and CNC homology 1, basic leucine zipper transcription factor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]
Chromosome	21
Cytoband	q21.3
Chromosome location (bp)	29194071 - 29630751
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156273 (version 78.38)
Entrez gene	571
UniProt	O14867 (UniProt - Evidence at protein level)
neXtProt	NX_O14867
Antibodypedia	BACH1 antibodies

PROTEIN VIEW

? »

BACH1-001		BACH1-002		BACH1-003		BACH1-004		BACH1-005		BACH1-006		BACH1-007		BACH1-009		BACH1-010		BACH1-011		BACH1-012		BACH1-013

PROTEIN INFORMATION

? »

Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
BACH1-001	ENSP00000286800 ENST00000286800	O14867 Show all » « Hide O14867 [Direct mapping] Transcription regulator protein BACH1 Q6ICU0 [Target identity:100%; Query identity:100%] BACH1 protein {ECO:0000313\|EMBL:CAG29299.1}; BTB and CNC homology 1, basic leucine zipper transcription factor 1, isoform CRA_a {ECO:0000313\|EMBL:EAX09913.1}; cDNA, FLJ94404, Homo sapiens BTB and CNC homology 1, basic leucine zippertranscription factor 1 (BACH1), mRNA {ECO:0000313\|EMBL:BAG36528.1} C9IYR0 [Target identity:30%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000400576} C9JMP6 [Target identity:29%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000408605} C9IYH8 [Target identity:23%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000392202} F8VZL7 [Target identity:3%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000447332}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000117 [regulation of transcription involved in G2/M transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0020037 [heme binding] GO:0043565 [sequence-specific DNA binding] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]	736	82	No	0
BACH1-002	ENSP00000382805 ENST00000399921	O14867 Show all » « Hide O14867 [Direct mapping] Transcription regulator protein BACH1 Q6ICU0 [Target identity:100%; Query identity:100%] BACH1 protein {ECO:0000313\|EMBL:CAG29299.1}; BTB and CNC homology 1, basic leucine zipper transcription factor 1, isoform CRA_a {ECO:0000313\|EMBL:EAX09913.1}; cDNA, FLJ94404, Homo sapiens BTB and CNC homology 1, basic leucine zippertranscription factor 1 (BACH1), mRNA {ECO:0000313\|EMBL:BAG36528.1} C9IYR0 [Target identity:30%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000400576} C9JMP6 [Target identity:29%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000408605} C9IYH8 [Target identity:23%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000392202} F8VZL7 [Target identity:3%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000447332}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000117 [regulation of transcription involved in G2/M transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription] GO:0001205 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001206 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0020037 [heme binding] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]	736	82	No	0
BACH1-003	ENSP00000392202 ENST00000435072	C9IYH8 Show all » « Hide C9IYH8 [Target identity:100%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000392202} F8VZL7 [Target identity:14%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000447332}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	170	19.4	No	0
BACH1-004	ENSP00000400576 ENST00000451655	C9IYR0 Show all » « Hide C9IYR0 [Target identity:99%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000400576} C9JMP6 [Target identity:97%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000408605} C9IYH8 [Target identity:75%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000392202} F8VZL7 [Target identity:11%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000447332}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	225	25.5	No	0
BACH1-005	ENSP00000408605 ENST00000447177	C9JMP6 Show all » « Hide C9JMP6 [Target identity:100%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000408605} C9IYH8 [Target identity:77%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000392202} F8VZL7 [Target identity:11%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000447332}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	220	25	No	0
BACH1-006	ENSP00000416569 ENST00000422809		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding]	218	24.5	No	0
BACH1-007	ENSP00000470673 ENST00000468059		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding]	138	15.6	No	0
BACH1-009	ENSP00000448982 ENST00000548467	F8VZL7 Show all » « Hide F8VZL7 [Target identity:100%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000447332}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		25	2.7	No	0
BACH1-010	ENSP00000447332 ENST00000548219	F8VZL7 Show all » « Hide F8VZL7 [Target identity:100%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000447332}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		25	2.7	No	0
BACH1-011	ENSP00000449316 ENST00000550131	F8VZL7 Show all » « Hide F8VZL7 [Target identity:100%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000447332}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		25	2.7	No	0
BACH1-012	ENSP00000448663 ENST00000547141	F8VZL7 Show all » « Hide F8VZL7 [Target identity:100%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000447332}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		25	2.7	No	0
BACH1-013	ENSP00000449383 ENST00000546469	F8VZL7 Show all » « Hide F8VZL7 [Target identity:100%; Query identity:100%] Transcription regulator protein BACH1 {ECO:0000313\|Ensembl:ENSP00000447332}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		25	2.7	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.