SLC25A27

GENE INFORMATION

? »

Gene name

SLC25A27 (HGNC Symbol)

Synonyms

FLJ33552, UCP4

Description

Solute carrier family 25, member 27 (HGNC Symbol)

Entrez gene summary

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Chromosome

6

Cytoband

p12.3

Chromosome location (bp)

46652915 - 46678193

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000153291 (version 78.38)

Entrez gene

9481

UniProt

O95847 (UniProt - Evidence at protein level)

neXtProt

NX_O95847

Antibodypedia

SLC25A27 antibodies
 

PROTEIN VIEW

? »
 
 
 
SLC25A27-001
 
SLC25A27-003
 
SLC25A27-004
 
SLC25A27-005
 
SLC25A27-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC25A27-001 ENSP00000360398
ENST00000371347
O95847
Show all »
Show » Show » 323 36.1 No 0
SLC25A27-003 ENSP00000474429
ENST00000604217
Show » 145 15.9 No 0
SLC25A27-004 ENSP00000474781
ENST00000603486
Q5VTS8
Show all »
Show » Show » 149 17 No 0
SLC25A27-005 ENSP00000473804
ENST00000604616
Show » 98 10.7 No 0
SLC25A27-201 ENSP00000412024
ENST00000411689
O95847
Show all »
Show » Show » 245 27.2 No 0