RANBP2

GENE INFORMATION

? »

Gene name

RANBP2 (HGNC Symbol)

Synonyms

ADANE, ANE1, NUP358

Description

RAN binding protein 2 (HGNC Symbol)

Entrez gene summary

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q13

Chromosome location (bp)

108719481 - 108785811

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000153201 (version 78.38)

Entrez gene

5903

UniProt

P49792 (UniProt - Evidence at protein level)

neXtProt

NX_P49792

Antibodypedia

RANBP2 antibodies
 

PROTEIN VIEW

? »
 
 
 
RANBP2-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RANBP2-001 ENSP00000283195
ENST00000283195
P49792
Show all »
Show » Show » 3224 358.2 No 0