BMP6

GENERAL INFORMATION

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Gene name

BMP6

Gene description

Bone morphogenetic protein 6

Protein class

Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (placenta)
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Data reliability

Uncertain based on 1 antibody.
CAB002773
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (placenta)

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

BMP6 (HGNC Symbol)

Synonyms

VGR, VGR1

Description

Bone morphogenetic protein 6 (HGNC Symbol)

Entrez gene summary

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p24.3

Chromosome location (bp)

7726797 - 7881422

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000153162 (version 78.38)

Entrez gene

654

UniProt

P22004 (UniProt - Evidence at protein level)

neXtProt

NX_P22004

Antibodypedia

BMP6 antibodies


PROTEIN BROWSER

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ENST00000283147
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BMP6-001 ENSP00000283147
ENST00000283147
P22004
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