GRM1 - Gene info - The Human Protein Atlas

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GRM1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	GRM1 (HGNC Symbol)
Synonyms	GPRC1A, mGlu1, MGLUR1, PPP1R85
Description	Glutamate receptor, metabotropic 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Chromosome	6
Cytoband	q24.3
Chromosome location (bp)	146027646 - 146437598
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152822 (version 78.38)
Entrez gene	2911
UniProt	Q13255 (UniProt - Evidence at protein level)
neXtProt	NX_Q13255
Antibodypedia	GRM1 antibodies

PROTEIN VIEW

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GRM1-001		GRM1-002		GRM1-019		GRM1-020		GRM1-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
GRM1-001	ENSP00000282753 ENST00000282753	Q13255 Show all » « Hide Q13255 [Direct mapping] Metabotropic glutamate receptor 1	Show » « Hide Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets	Show » « Hide GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0008219 [cell death] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038038 [G-protein coupled receptor homodimeric complex] GO:0038042 [dimeric G-protein coupled receptor signaling pathway] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051966 [regulation of synaptic transmission, glutamatergic]	1194	132.4	Yes	7
GRM1-002	ENSP00000424095 ENST00000492807	Q13255 Show all » « Hide Q13255 [Direct mapping] Metabotropic glutamate receptor 1	Show » « Hide Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets	Show » « Hide GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0008219 [cell death] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038038 [G-protein coupled receptor homodimeric complex] GO:0038042 [dimeric G-protein coupled receptor signaling pathway] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051966 [regulation of synaptic transmission, glutamatergic]	906	101.3	Yes	7
GRM1-019	ENSP00000347437 ENST00000355289	Q13255 Show all » « Hide Q13255 [Direct mapping] Metabotropic glutamate receptor 1	Show » « Hide Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets	Show » « Hide GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0008219 [cell death] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038038 [G-protein coupled receptor homodimeric complex] GO:0038042 [dimeric G-protein coupled receptor signaling pathway] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051966 [regulation of synaptic transmission, glutamatergic]	908	101.5	Yes	7
GRM1-020	ENSP00000425599 ENST00000507907	Q13255 Show all » « Hide Q13255 [Direct mapping] Metabotropic glutamate receptor 1	Show » « Hide Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets	Show » « Hide GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0008219 [cell death] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038038 [G-protein coupled receptor homodimeric complex] GO:0038042 [dimeric G-protein coupled receptor signaling pathway] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051966 [regulation of synaptic transmission, glutamatergic]	906	101.3	Yes	7
GRM1-201	ENSP00000354896 ENST00000361719	Q13255 Show all » « Hide Q13255 [Direct mapping] Metabotropic glutamate receptor 1	Show » « Hide Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets	Show » « Hide GO:0000186 [activation of MAPKK activity] GO:0000187 [activation of MAPK activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007626 [locomotory behavior] GO:0008066 [glutamate receptor activity] GO:0008219 [cell death] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0019233 [sensory perception of pain] GO:0030425 [dendrite] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038038 [G-protein coupled receptor homodimeric complex] GO:0038042 [dimeric G-protein coupled receptor signaling pathway] GO:0043005 [neuron projection] GO:0043408 [regulation of MAPK cascade] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051930 [regulation of sensory perception of pain] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0071257 [cellular response to electrical stimulus]	1194	132.4	Yes	7

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.