RASGRP3

GENE INFORMATION

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Gene name

RASGRP3 (HGNC Symbol)

Synonyms

GRP3, KIAA0846

Description

RAS guanyl releasing protein 3 (calcium and DAG-regulated) (HGNC Symbol)

Entrez gene summary

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

Chromosome

2

Cytoband

p22.3

Chromosome location (bp)

33436324 - 33564750

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000152689 (version 78.38)

Entrez gene

25780

UniProt

Q8IV61 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8IV61

Antibodypedia

RASGRP3 antibodies
 

PROTEIN VIEW

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RASGRP3-001
 
RASGRP3-004
 
RASGRP3-006
 
RASGRP3-007
 
RASGRP3-008
 
RASGRP3-012
 
RASGRP3-013
 
RASGRP3-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RASGRP3-001 ENSP00000385886
ENST00000402538
Q8IV61
Show all »
Show » Show » 690 78.3 No 0
RASGRP3-004 ENSP00000383917
ENST00000407811
C9K0P4
Show all »
Show » Show » 689 78.2 No 0
RASGRP3-006 ENSP00000384192
ENST00000403687
Q8IV61
Show all »
Show » Show » 690 78.3 No 0
RASGRP3-007 ENSP00000393866
ENST00000437184
C9K0P4
Show all »
Show » Show » 172 20.2 No 0
RASGRP3-008 ENSP00000401974
ENST00000425210
C9JSS2
Show all »
Show » 34 3.6 No 0
RASGRP3-012 ENSP00000405648
ENST00000442390
C9J9C9
Show all »
Show » Show » 77 8.8 No 0
RASGRP3-013 ENSP00000388139
ENST00000423159
C9JWP0
Show all »
Show » Show » 113 13.2 No 0
RASGRP3-014 ENSP00000400602
ENST00000444784
C9IYA5
Show all »
Show » Show » 112 13.1 No 0