DMP1

GENE INFORMATION

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Gene name

DMP1

Synonyms

Description

Dentin matrix acidic phosphoprotein 1 (HGNC Symbol)

Entrez gene summary

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q22.1

Chromosome location (bp)

87650307 - 87664361

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000152592 (version 78.38)

Entrez gene

1758

UniProt

Q13316 (UniProt - Evidence at protein level)

neXtProt

NX_Q13316

Antibodypedia

DMP1 antibodies
 

PROTEIN VIEW

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DMP1-001
 
DMP1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DMP1-001 ENSP00000340935
ENST00000339673
Q13316
Show all »
Show » Show » 513 55.8 Yes 0
DMP1-002 ENSP00000282479
ENST00000282479
Q13316
Show all »
Show » Show » 497 54.1 Yes 0