XRCC4

GENE INFORMATION

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Gene name

XRCC4

Synonyms

Description

X-ray repair complementing defective repair in Chinese hamster cells 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq, Sep 2008]

Chromosome

5

Cytoband

q14.2

Chromosome location (bp)

83077498 - 83353787

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000152422 (version 78.38)

Entrez gene

7518

UniProt

Q13426 (UniProt - Evidence at protein level)

neXtProt

NX_Q13426

Antibodypedia

XRCC4 antibodies
 

PROTEIN VIEW

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XRCC4-001
 
XRCC4-002
 
XRCC4-003
 
XRCC4-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

XRCC4-001 ENSP00000379344
ENST00000396027
Q13426
Show all »
Show » Show » 334 38.1 No 0
XRCC4-002 ENSP00000342011
ENST00000338635
Q13426
Show all »
Show » Show » 336 38.3 No 0
XRCC4-003 ENSP00000421491
ENST00000511817
Q13426
Show all »
Show » Show » 336 38.3 No 0
XRCC4-201 ENSP00000282268
ENST00000282268
Q13426
Show all »
Show » Show » 334 38.1 No 0