|
|
GENE INFORMATION
? »
|
The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version.
The Entrez gene identifier for the gene is also given. If any of the protein products of
the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the
neXtProt databases for these proteins are displayed.
There is also a link to the Antibodypedia portal where validation data for antibodies produced by other suppliers
against this gene can be found.
|
Gene name |
ATP5A1 (HGNC Symbol) |
Synonyms |
ATP5A, ATP5AL2, ATPM, hATP1, OMR, ORM |
Description |
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (HGNC Symbol) |
Entrez gene summary |
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. [provided by RefSeq, Mar 2012] |
Chromosome |
18 |
Cytoband |
q21.1 |
Chromosome location (bp) |
46080248 - 46104334 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000152234 (version 78.38) |
Entrez gene |
498 |
UniProt |
P25705 (UniProt - Evidence at protein level) |
neXtProt |
NX_P25705 |
Antibodypedia |
ATP5A1 antibodies |
|
| |
|
|
PROTEIN VIEW
? »
|
The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues
(HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius
(turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed
( read more), and at the bottom of the protein view is the protein scale.
|
|
|
| |
|
|
PROTEIN INFORMATION
? »
|
The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant.
The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors
SPOCTOPUS,
SignalP 4.0, and
Phobius) and the number of predicted transmembrane region(s) (according to
MDM) are also reported.
|
Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length
(aa) |
Molecular mass
(kDa) |
Signal peptide
(predicted) |
Transmembrane regions
(predicted)
|
| ATP5A1-001 |
ENSP00000381736
ENST00000398752
|
P25705
Show all »
« Hide
P25705 [Direct mapping]ATP synthase subunit alpha, mitochondrial V9HW26 [Target identity:100%; Query identity:100%]ATP synthase subunit alpha {ECO:0000256|RuleBase:RU003551} K7EK77 [Target identity:37%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000465497} K7ERX7 [Target identity:37%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000468458} B4DGW3 [Target identity:30%; Query identity:100%]cDNA FLJ54625, highly similar to ATP synthase subunit alpha, mitochondrial {ECO:0000313|EMBL:BAG57924.1} K7EJP1 [Target identity:26%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000465259} K7EQH4 [Target identity:20%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000467830}
|
Show »
« Hide
Predicted intracellular proteins
Plasma proteins
Mitochondrial proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
|
553 |
59.7 |
No |
0 |
| ATP5A1-003 |
ENSP00000465497
ENST00000589869
|
K7EK77
Show all »
« Hide
K7EK77 [Target identity:100%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000465497} B4DGW3 [Target identity:80%; Query identity:100%]cDNA FLJ54625, highly similar to ATP synthase subunit alpha, mitochondrial {ECO:0000313|EMBL:BAG57924.1} K7EJP1 [Target identity:69%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000465259} K7EQH4 [Target identity:53%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000467830}
|
Show »
« Hide
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
|
207 |
22.2 |
No |
0 |
| ATP5A1-004 |
ENSP00000465259
ENST00000590324
|
K7EJP1
Show all »
« Hide
K7EJP1 [Target identity:99%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000465259} K7EQH4 [Target identity:76%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000467830}
|
Show »
« Hide
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
|
145 |
15.3 |
No |
0 |
| ATP5A1-005 |
ENSP00000468458
ENST00000590406
|
K7ERX7
Show all »
« Hide
K7ERX7 [Target identity:100%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000468458} K7EJP1 [Target identity:70%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000465259} K7EQH4 [Target identity:54%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000467830}
|
Show »
« Hide
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
|
205 |
21.6 |
No |
0 |
| ATP5A1-009 |
ENSP00000467037
ENST00000590665
|
P25705
Show all »
« Hide
P25705 [Direct mapping]ATP synthase subunit alpha, mitochondrial
|
Show »
« Hide
Predicted intracellular proteins
Plasma proteins
Mitochondrial proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
|
531 |
57.5 |
No |
0 |
| ATP5A1-016 |
ENSP00000467830
ENST00000592989
|
K7EQH4
Show all »
« Hide
K7EQH4 [Target identity:100%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000467830}
|
Show »
« Hide
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
|
111 |
11.7 |
No |
0 |
| ATP5A1-018 |
ENSP00000466975
ENST00000589252
|
K7ENJ4
Show all »
« Hide
K7ENJ4 [Target identity:100%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000466975}
|
Show »
« Hide
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
|
199 |
21.3 |
No |
0 |
| ATP5A1-201 |
ENSP00000282050
ENST00000282050
|
P25705
Show all »
« Hide
P25705 [Direct mapping]ATP synthase subunit alpha, mitochondrial V9HW26 [Target identity:100%; Query identity:100%]ATP synthase subunit alpha {ECO:0000256|RuleBase:RU003551} K7EK77 [Target identity:37%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000465497} K7ERX7 [Target identity:37%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000468458} B4DGW3 [Target identity:30%; Query identity:100%]cDNA FLJ54625, highly similar to ATP synthase subunit alpha, mitochondrial {ECO:0000313|EMBL:BAG57924.1} K7EJP1 [Target identity:26%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000465259} K7EQH4 [Target identity:20%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000467830}
|
Show »
« Hide
Predicted intracellular proteins
Plasma proteins
Mitochondrial proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
|
553 |
59.7 |
No |
0 |
| ATP5A1-202 |
ENSP00000465477
ENST00000593152
|
P25705
Show all »
« Hide
P25705 [Direct mapping]ATP synthase subunit alpha, mitochondrial K7EK77 [Target identity:41%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000465497} B4DGW3 [Target identity:33%; Query identity:100%]cDNA FLJ54625, highly similar to ATP synthase subunit alpha, mitochondrial {ECO:0000313|EMBL:BAG57924.1} K7EJP1 [Target identity:28%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000465259} K7EQH4 [Target identity:22%; Query identity:100%]ATP synthase subunit alpha, mitochondrial {ECO:0000313|Ensembl:ENSP00000467830}
|
Show »
« Hide
Predicted intracellular proteins
Plasma proteins
Mitochondrial proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
|
503 |
54.5 |
No |
0 |
|
|
|
|
|
|
