PTPRO - Gene info - The Human Protein Atlas

Gene name

PTPRO (HGNC Symbol)

Synonyms

GLEPP1, NPHS6, PTP-oc, PTP-U2, PTPU2

Description

Protein tyrosine phosphatase, receptor type, O (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]

Chromosome

Cytoband

p12.3

Chromosome location (bp)

15322397 - 15597399

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151490 (version 78.38)

Entrez gene

5800

UniProt

Q16827 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPRO-001

ENSP00000281171
ENST00000281171

Q16827
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Q16827 [Direct mapping]
Receptor-type tyrosine-protein phosphatase O
A0A024RAS9 [Target identity:33%; Query identity:100%]
Protein tyrosine phosphatase, receptor type, O, isoform CRA_d {ECO:0000313|EMBL:EAW96352.1}
B4DS16 [Target identity:23%; Query identity:100%]
cDNA FLJ58276, highly similar to Receptor-type tyrosine-protein phosphatase O {ECO:0000313|EMBL:BAG61478.1}

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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000902 [cell morphogenesis]
GO:0002548 [monocyte chemotaxis]
GO:0003093 [regulation of glomerular filtration]
GO:0003105 [negative regulation of glomerular filtration]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007411 [axon guidance]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0010977 [negative regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016791 [phosphatase activity]
GO:0017147 [Wnt-protein binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0032835 [glomerulus development]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0036060 [slit diaphragm assembly]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0070062 [extracellular vesicular exosome]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090260 [negative regulation of retinal ganglion cell axon guidance]

1216

138.3

Yes

PTPRO-002

ENSP00000343434
ENST00000348962

Q16827
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Q16827 [Direct mapping]
Receptor-type tyrosine-protein phosphatase O
A0A024RAS0 [Target identity:31%; Query identity:100%]
Protein tyrosine phosphatase, receptor type, O, isoform CRA_c {ECO:0000313|EMBL:EAW96353.1}
B4DS16 [Target identity:24%; Query identity:100%]
cDNA FLJ58276, highly similar to Receptor-type tyrosine-protein phosphatase O {ECO:0000313|EMBL:BAG61478.1}

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1188

134.9

Yes

PTPRO-003

ENSP00000444173
ENST00000543886

Q16827
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Q16827 [Direct mapping]
Receptor-type tyrosine-protein phosphatase O

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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000902 [cell morphogenesis]
GO:0002548 [monocyte chemotaxis]
GO:0003093 [regulation of glomerular filtration]
GO:0003105 [negative regulation of glomerular filtration]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007411 [axon guidance]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0010977 [negative regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016791 [phosphatase activity]
GO:0017147 [Wnt-protein binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0032835 [glomerulus development]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0036060 [slit diaphragm assembly]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0070062 [extracellular vesicular exosome]
GO:0072112 [glomerular visceral epithelial cell differentiation]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090260 [negative regulation of retinal ganglion cell axon guidance]

597

67.7

Yes

PTPRO-004

ENSP00000404188
ENST00000442921

Q16827
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Q16827 [Direct mapping]
Receptor-type tyrosine-protein phosphatase O
A0A024RAS9 [Target identity:100%; Query identity:100%]
Protein tyrosine phosphatase, receptor type, O, isoform CRA_d {ECO:0000313|EMBL:EAW96352.1}
B4DS16 [Target identity:70%; Query identity:100%]
cDNA FLJ58276, highly similar to Receptor-type tyrosine-protein phosphatase O {ECO:0000313|EMBL:BAG61478.1}

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405

47.2

PTPRO-005

ENSP00000437571
ENST00000542557

Q16827
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Q16827 [Direct mapping]
Receptor-type tyrosine-protein phosphatase O
A0A024RAS0 [Target identity:100%; Query identity:100%]
Protein tyrosine phosphatase, receptor type, O, isoform CRA_c {ECO:0000313|EMBL:EAW96353.1}
B4DS16 [Target identity:76%; Query identity:100%]
cDNA FLJ58276, highly similar to Receptor-type tyrosine-protein phosphatase O {ECO:0000313|EMBL:BAG61478.1}

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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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377

43.8

PTPRO-006

ENSP00000393449
ENST00000445537

Q16827
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Show » « Hide

405

47.2

PTPRO-007

ENSP00000439234
ENST00000544244

Q16827
Show all » « Hide

Show » « Hide

Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

377

43.8

PTPRO-012

ENSP00000446201
ENST00000535322

H0YH60
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H0YH60 [Target identity:100%; Query identity:100%]
Receptor-type tyrosine-protein phosphatase O {ECO:0000313|Ensembl:ENSP00000446201}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004725 [protein tyrosine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0035335 [peptidyl-tyrosine dephosphorylation]

116

13.8

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.