PAK1

GENERAL INFORMATION

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Gene name

PAK1

Gene description

P21 protein (Cdc42/Rac)-activated kinase 1

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

10
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most cell types, high expression in neuronal cells of the CNS.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA003565 , CAB005312
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PAK1

Synonyms

Description

P21 protein (Cdc42/Rac)-activated kinase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Chromosome

11

Cytoband

Chromosome location (bp)

77321707 - 77474635

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000149269 (version 78.38)

Entrez gene

5058

UniProt

Q13153 (UniProt - Evidence at protein level)

neXtProt

NX_Q13153

Antibodypedia

PAK1 antibodies


PROTEIN BROWSER

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ENST00000278568
 
ENST00000356341
 
ENST00000524847
 
ENST00000526968
 
ENST00000528203
 
ENST00000528592
 
ENST00000528633
 
ENST00000529248
 
ENST00000530617
 
ENST00000533285
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PAK1-001 ENSP00000348696
ENST00000356341
Q13153
Show all »
Show » Show » 545 60.6 No 0
PAK1-002 ENSP00000278568
ENST00000278568
Q13153
Show all »
Show » Show » 553 61.6 No 0
PAK1-003 ENSP00000433423
ENST00000530617
B3KNX7
Show all »
Show » Show » 522 58.2 No 0
PAK1-004 ENSP00000433211
ENST00000528203
E9PM17
Show all »
Show » Show » 455 50.9 No 0
PAK1-006 ENSP00000433737
ENST00000526968
E9PJF8
Show all »
Show » 26 2.8 No 0
PAK1-007 ENSP00000432477
ENST00000524847
E9PQW5
Show all »
Show » 99 10.9 No 0
PAK1-009 ENSP00000433518
ENST00000529248
E9PKH9
Show all »
Show » 106 11.8 No 0
PAK1-010 ENSP00000435983
ENST00000528633
E9PRP6
Show all »
Show » 63 6.8 No 0
PAK1-011 ENSP00000433004
ENST00000528592
E9PMP2
Show all »
Show » 89 9.9 No 0
PAK1-018 ENSP00000431541
ENST00000533285
Show » Show » 244 27.1 No 0