SESN3

GENE INFORMATION

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Gene name

SESN3 (HGNC Symbol)

Synonyms

MGC29667, SEST3

Description

Sestrin 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Chromosome

11

Cytoband

q21

Chromosome location (bp)

95165540 - 95232541

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000149212 (version 78.38)

Entrez gene

143686

UniProt

P58005 (UniProt - Evidence at transcript level)

neXtProt

NX_P58005

Antibodypedia

SESN3 antibodies
 

PROTEIN VIEW

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SESN3-001
 
SESN3-002
 
SESN3-003
 
SESN3-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SESN3-001 ENSP00000441927
ENST00000536441
P58005
Show all »
Show » Show » 492 57.3 No 0
SESN3-002 ENSP00000407008
ENST00000416495
P58005
Show all »
Show » Show » 321 36.6 No 0
SESN3-003 ENSP00000278499
ENST00000278499
P58005
Show all »
Show » Show » 353 41.5 No 0
SESN3-004 ENSP00000439580
ENST00000542176
F5H1K7
Show all »
Show » Show » 70 8.1 No 0