SERPING1

GENE INFORMATION

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Gene name

SERPING1 (HGNC Symbol)

Synonyms

C1-INH, C1IN, C1NH, HAE1, HAE2

Description

Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q12.1

Chromosome location (bp)

57597387 - 57614853

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000149131 (version 78.38)

Entrez gene

710

UniProt

P05155 (UniProt - Evidence at protein level)

neXtProt

NX_P05155

Antibodypedia

SERPING1 antibodies
 

PROTEIN VIEW

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SERPING1-001
 
SERPING1-002
 
SERPING1-003
 
SERPING1-004
 
SERPING1-005
 
SERPING1-006
 
SERPING1-007
 
SERPING1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SERPING1-001 ENSP00000278407
ENST00000278407
P05155
Show all »
Show » Show » 500 55.2 Yes 0
SERPING1-002 ENSP00000384420
ENST00000403558
E9PGN7
Show all »
Show » Show » 543 59.5 No 0
SERPING1-003 ENSP00000399746
ENST00000457869
C9JZJ9
Show all »
Show » 122 12.5 No 0
SERPING1-004 ENSP00000384561
ENST00000405496
B5MCB9
Show all »
Show » Show » 160 16.8 Yes 0
SERPING1-005 ENSP00000367574
ENST00000378323
P05155
Show all »
Show » Show » 505 55.8 Yes 0
SERPING1-006 ENSP00000341861
ENST00000340687
H9KV48
Show all »
Show » Show » 463 51 Yes 0
SERPING1-007 ENSP00000367575
ENST00000378324
P05155
Show all »
Show » Show » 448 49.8 No 0
SERPING1-201 ENSP00000478572
ENST00000619430
Show » 133 14.1 Yes 0