SIGMAR1

GENE INFORMATION

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Gene name

SIGMAR1 (HGNC Symbol)

Synonyms

OPRS1, SR-BP1

Description

Sigma non-opioid intracellular receptor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013]

Chromosome

9

Cytoband

p13.3

Chromosome location (bp)

34634722 - 34637809

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147955 (version 78.38)

Entrez gene

10280

UniProt

Q99720 (UniProt - Evidence at protein level)

neXtProt

NX_Q99720

Antibodypedia

SIGMAR1 antibodies
 

PROTEIN VIEW

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SIGMAR1-001
 
SIGMAR1-002
 
SIGMAR1-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SIGMAR1-001 ENSP00000277010
ENST00000277010
Q99720
Show all »
Show » Show » 223 25.1 No 1
SIGMAR1-002 ENSP00000368170
ENST00000378892
Q5T1J1
Show all »
Show » Show » 134 14.9 Yes 0
SIGMAR1-008 ENSP00000420022
ENST00000477726
Q99720
Show all »
Show » Show » 192 21.5 No 1