CHRNB3

GENE INFORMATION

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Gene name

CHRNB3

Synonyms

Description

Cholinergic receptor, nicotinic, beta 3 (neuronal) (HGNC Symbol)

Entrez gene summary

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010]

Chromosome

8

Cytoband

p11.21

Chromosome location (bp)

42697376 - 42737407

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000147432 (version 78.38)

Entrez gene

1142

UniProt

Q05901 (UniProt - Evidence at transcript level)

neXtProt

NX_Q05901

Antibodypedia

CHRNB3 antibodies
 

PROTEIN VIEW

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CHRNB3-001
 
CHRNB3-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHRNB3-001 ENSP00000289957
ENST00000289957
Q05901
Show all »
Show » Show » 458 52.7 Yes 4
CHRNB3-002 ENSP00000433913
ENST00000534391
Show » 9 1.1 No 0