ATP6V1B2

GENE INFORMATION

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Gene name

ATP6V1B2 (HGNC Symbol)

Synonyms

ATP6B2, HO57, VATB, Vma2, VPP3

Description

ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 (HGNC Symbol)

Entrez gene summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

p21.3

Chromosome location (bp)

20197367 - 20226819

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147416 (version 78.38)

Entrez gene

526

UniProt

P21281 (UniProt - Evidence at protein level)

neXtProt

NX_P21281

Antibodypedia

ATP6V1B2 antibodies
 

PROTEIN VIEW

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ATP6V1B2-001
 
ATP6V1B2-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V1B2-001 ENSP00000276390
ENST00000276390
P21281
Show all »
Show » Show » 511 56.5 No 0
ATP6V1B2-005 ENSP00000430682
ENST00000519667
Show » Show » 199 21 No 0