SCUBE3

GENE INFORMATION

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Gene name

SCUBE3 (HGNC Symbol)

Synonyms

CEGF3, FLJ34743

Description

Signal peptide, CUB domain, EGF-like 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the signal peptide, complement subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1 and epidermal growth factor-like domain containing protein family. Overexpression of this gene in human embryonic kidney cells results in secretion of a glycosylated form of the protein that forms oligomers and tethers to the cell surface. This gene is upregulated in lung cancer tumor tissue compared to healthy tissue and is associated with loss of the epithelial marker E-cadherin and with increased expression of vimentin, a mesenchymal marker. In addition, the protein encoded by this gene is a transforming growth factor beta receptor ligand, and when secreted by cancer cells, it can be cleaved in vitro to release the N-terminal epidermal growth factor-like repeat domain and the C-terminal complement subcomponents C1r/C1s domain. Both the full length protein and C-terminal fragment can bind to the transforming growth factor beta type II receptor to promote the epithelial-mesenchymal transition and tumor angiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Chromosome

6

Cytoband

p21.31

Chromosome location (bp)

35214419 - 35253079

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000146197 (version 78.38)

Entrez gene

222663

UniProt

Q8IX30 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IX30

Antibodypedia

SCUBE3 antibodies
 

PROTEIN VIEW

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SCUBE3-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SCUBE3-001 ENSP00000274938
ENST00000274938
Q8IX30
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