GC

GENERAL INFORMATION

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Gene name

GC

Gene description

Group-specific component (vitamin D binding protein)

Protein class

Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein localization

Distinct staining of extracellular deposits.

ANTIBODY RELIABILITY

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Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Data reliability

Supportive based on 3 antibodies.
HPA001526 , HPA019855 , CAB008596
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression



GENE INFORMATION

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Gene name

GC (HGNC Symbol)

Synonyms

DBP, hDBP, VDBP

Description

Group-specific component (vitamin D binding protein) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Chromosome

4

Cytoband

q13.3

Chromosome location (bp)

71741693 - 71804041

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000145321 (version 78.38)

Entrez gene

2638

UniProt

P02774 (UniProt - Evidence at protein level)

neXtProt

NX_P02774

Antibodypedia

GC antibodies


PROTEIN BROWSER

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ENST00000273951
 
ENST00000504199
 
ENST00000506245
 
ENST00000513476
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GC-001 ENSP00000273951
ENST00000273951
P02774
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Show » Show » 474 52.9 Yes 0
GC-004 ENSP00000426683
ENST00000513476
D6RF35
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Show » Show » 476 53 Yes 0
GC-006 ENSP00000421725
ENST00000504199
P02774
Show all »
Show » Show » 493 55.1 Yes 0
GC-007 ENSP00000426718
ENST00000506245
D6RF20
Show all »
Show » Show » 145 16.1 Yes 0