MANF

GENE INFORMATION

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Gene name

MANF (HGNC Symbol)

Synonyms

ARMET, ARP

Description

Mesencephalic astrocyte-derived neurotrophic factor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]

Chromosome

3

Cytoband

p21.2

Chromosome location (bp)

51385047 - 51389397

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000145050 (version 78.38)

Entrez gene

7873

UniProt

P55145 (UniProt - Evidence at protein level)

neXtProt

NX_P55145

Antibodypedia

MANF antibodies
 

PROTEIN VIEW

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MANF-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MANF-001 ENSP00000432799
ENST00000528157
P55145
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