ACKR2

GENE INFORMATION

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Gene name

ACKR2 (HGNC Symbol)

Synonyms

CCBP2, CCR10, CCR9, CMKBR9, D6

Description

Atypical chemokine receptor 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p22.1

Chromosome location (bp)

42804752 - 42887974

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000144648 (version 78.38)

Entrez gene

1238

UniProt

O00590 (UniProt - Evidence at protein level)

neXtProt

NX_O00590

Antibodypedia

ACKR2 antibodies
 

PROTEIN VIEW

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ACKR2-001
 
ACKR2-003
 
ACKR2-007
 
ACKR2-011
 
ACKR2-012
 
ACKR2-013
 
ACKR2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACKR2-001 ENSP00000416996
ENST00000422265
O00590
Show all »
Show » Show » 384 43.4 No 7
ACKR2-003 ENSP00000396150
ENST00000442925
O00590
Show all »
Show » Show » 384 43.4 No 7
ACKR2-007 ENSP00000476901
ENST00000497921
V9GYM0
Show all »
Show » Show » 125 14.3 No 2
ACKR2-011 ENSP00000477475
ENST00000492609
V9GZ70
Show all »
Show » Show » 142 16.3 No 3
ACKR2-012 ENSP00000477157
ENST00000494619
V9GYX0
Show all »
Show » Show » 170 19.6 No 3
ACKR2-013 ENSP00000476581
ENST00000493193
V9GYB7
Show all »
Show » Show » 233 26.8 No 5
ACKR2-201 ENSP00000273145
ENST00000273145
O00590
Show all »
Show » Show » 384 43.4 No 7