FLG

GENE INFORMATION

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Gene name

FLG

Synonyms

Description

Filaggrin (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]

Chromosome

1

Cytoband

q21.3

Chromosome location (bp)

152302175 - 152325203

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143631 (version 78.38)

Entrez gene

2312

UniProt

P20930 (UniProt - Evidence at protein level)

neXtProt

NX_P20930

Antibodypedia

FLG antibodies
 

PROTEIN VIEW

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FLG-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FLG-001 ENSP00000357789
ENST00000368799
P20930
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