SYT14

GENERAL INFORMATION

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Gene name

SYT14

Gene description

Synaptotagmin XIV

Protein class

Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (testis, thyroid gland)
GTEx:Tissue enhanced (cerebellum, testis)

Protein evidence

Evidence at protein level

Protein localization

Placental trophoblasts and a subset of renal tubules displayed strong cytoplasmic and membranous immunoreactivity. Moderate staining was observed in the gastrointestinal tract, hepatocytes, gall bladder, adrenal cortex, endometrial glands, Purkinje cells, cells in male genital tract and decidual cells. Remaining normal cells were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA036963
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (testis, thyroid gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebellum, testis)

Organ

Expression



GENE INFORMATION

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Gene name

SYT14 (HGNC Symbol)

Synonyms

FLJ34198, sytXIV

Description

Synaptotagmin XIV (HGNC Symbol)

Entrez gene summary

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent synaptotagmin. Mutations in this gene are a cause of autosomal recessive spinocerebellar ataxia-11 (SCAR11), and a t(1;3) translocation of this gene has been associated with neurodevelopmental abnormalities. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Dec 2011]

Chromosome

1

Cytoband

q32.2

Chromosome location (bp)

209938174 - 210171315

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143469 (version 78.38)

Entrez gene

255928

UniProt

Q8NB59 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NB59

Antibodypedia

SYT14 antibodies


PROTEIN BROWSER

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ENST00000367015
 
ENST00000367019
 
ENST00000472886
 
ENST00000534859
 
ENST00000537238
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SYT14-001 ENSP00000418901
ENST00000472886
Q8NB59
Show all »
Show » Show » 555 62.3 No 1
SYT14-003 ENSP00000355982
ENST00000367015
Q8NB59
Show all »
Show » Show » 517 58.3 No 0
SYT14-004 ENSP00000355986
ENST00000367019
Q8NB59
Show all »
Show » Show » 574 64.4 No 1
SYT14-005 ENSP00000442891
ENST00000534859
Show » Show » 504 56.6 No 0
SYT14-201 ENSP00000437423
ENST00000537238
Q8NB59
Show all »
Show » Show » 517 58.3 No 0