MCL1

GENE INFORMATION

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Gene name

MCL1 (HGNC Symbol)

Synonyms

BCL2L3, Mcl-1

Description

Myeloid cell leukemia 1 (HGNC Symbol)

Entrez gene summary

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

Chromosome

1

Cytoband

q21.2

Chromosome location (bp)

150574551 - 150579738

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143384 (version 78.38)

Entrez gene

4170

UniProt

Q07820 (UniProt - Evidence at protein level)

neXtProt

NX_Q07820

Antibodypedia

MCL1 antibodies
 

PROTEIN VIEW

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MCL1-001
 
MCL1-002
 
MCL1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MCL1-001 ENSP00000358022
ENST00000369026
Q07820
Show all »
Show » Show » 350 37.3 No 1
MCL1-002 ENSP00000309973
ENST00000307940
Q07820
Show all »
Show » Show » 271 28.7 No 0
MCL1-201 ENSP00000477624
ENST00000620947
Show » Show » 197 21.2 No 1