CD53

GENE INFORMATION

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Gene name

CD53 (HGNC Symbol)

Synonyms

MOX44, TSPAN25

Description

CD53 molecule (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p13.3

Chromosome location (bp)

110873154 - 110899928

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143119 (version 78.38)

Entrez gene

963

UniProt

P19397 (UniProt - Evidence at protein level)

neXtProt

NX_P19397

Antibodypedia

CD53 antibodies
 

PROTEIN VIEW

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CD53-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD53-001 ENSP00000271324
ENST00000271324
P19397
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