FCN3

GENE INFORMATION

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Gene name

FCN3 (HGNC Symbol)

Synonyms

FCNH, HAKA1

Description

Ficolin (collagen/fibrinogen domain containing) 3 (HGNC Symbol)

Entrez gene summary

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.11

Chromosome location (bp)

27369112 - 27374824

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142748 (version 78.38)

Entrez gene

8547

UniProt

O75636 (UniProt - Evidence at protein level)

neXtProt

NX_O75636

Antibodypedia

FCN3 antibodies
 

PROTEIN VIEW

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FCN3-001
 
FCN3-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FCN3-001 ENSP00000270879
ENST00000270879
O75636
Show all »
Show » Show » 299 32.9 Yes 0
FCN3-002 ENSP00000347077
ENST00000354982
O75636
Show all »
Show » Show » 288 31.7 Yes 0