TMC6

GENE INFORMATION

? »

Gene name

TMC6 (HGNC Symbol)

Synonyms

EVER1, EVIN1, LAK-4P

Description

Transmembrane channel-like 6 (HGNC Symbol)

Entrez gene summary

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q25.3

Chromosome location (bp)

78110458 - 78132407

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000141524 (version 78.38)

Entrez gene

11322

UniProt

Q7Z403 (UniProt - Evidence at transcript level)

neXtProt

NX_Q7Z403

Antibodypedia

TMC6 antibodies
 

PROTEIN VIEW

? »
 
 
 
TMC6-001
 
TMC6-002
 
TMC6-003
 
TMC6-007
 
TMC6-009
 
TMC6-010
 
TMC6-015
 
TMC6-016
 
TMC6-026
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TMC6-001 ENSP00000376260
ENST00000392467
Q7Z403
Show all »
Show » Show » 805 90 No 9
TMC6-002 ENSP00000313408
ENST00000322914
Q7Z403
Show all »
Show » Show » 805 90 No 9
TMC6-003 ENSP00000465359
ENST00000589553
Q7Z403
Show all »
Show » Show » 298 32.5 No 5
TMC6-007 ENSP00000465261
ENST00000590602
Q7Z403
Show all »
Show » Show » 805 90 No 9
TMC6-009 ENSP00000464853
ENST00000591436
Q7Z403
Show all »
Show » Show » 384 43.3 No 5
TMC6-010 ENSP00000467016
ENST00000592594
K7ENM6
Show all »
Show » 143 16.1 No 0
TMC6-015 ENSP00000468255
ENST00000589271
K7ERH0
Show all »
Show » 286 31.7 No 1
TMC6-016 ENSP00000466885
ENST00000592063
K7ENC4
Show all »
Show » 153 17.3 No 0
TMC6-026 ENSP00000306405
ENST00000306591
Q7Z403
Show all »
Show » Show » 454 50.3 No 2