Tissue expression of NTRK3 - Summary - The Human Protein Atlas

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NTRK3

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	NTRK3
Gene description	Neurotrophic tyrosine kinase, receptor, type 3
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Mixed

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues showed weak to moderate cytoplasmic and nuclear positivity. Neuronal cells of cerebral cortex and neuropil were strongly stained.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Uncertain based on 1 antibody. CAB009233
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Tissue enhanced (cerebral cortex)

Organ

Expression

GTEx dataset

RNA tissue category:

Mixed

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	NTRK3 (HGNC Symbol)
Synonyms	TRKC
Description	Neurotrophic tyrosine kinase, receptor, type 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Chromosome	15
Cytoband	q25.3
Chromosome location (bp)	87859751 - 88256768
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140538 (version 78.38)
Entrez gene	4916
UniProt	Q16288 (UniProt - Evidence at protein level)
neXtProt	NX_Q16288
Antibodypedia	NTRK3 antibodies

PROTEIN BROWSER

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ENST00000317501		ENST00000355254		ENST00000357724		ENST00000360948		ENST00000394480		ENST00000540489		ENST00000542733		ENST00000557856		ENST00000558576		ENST00000558676		ENST00000559188		ENST00000560017

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
NTRK3-001	ENSP00000377990 ENST00000394480	Q16288 Show all » « Hide Q16288 [Direct mapping] NT-3 growth factor receptor X5D7M5 [Target identity:100%; Query identity:100%] Tyrosine-protein kinase receptor {ECO:0000256\|RuleBase:RU000312} R4GNH5 [Target identity:10%; Query identity:100%] NT-3 growth factor receptor {ECO:0000313\|Ensembl:ENSP00000473656}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000187 [activation of MAPK activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030335 [positive regulation of cell migration] GO:0032148 [activation of protein kinase B activity] GO:0032856 [activation of Ras GTPase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0050927 [positive regulation of positive chemotaxis] GO:2000251 [positive regulation of actin cytoskeleton reorganization]	825	92.8	Yes	1
NTRK3-002	ENSP00000318328 ENST00000317501	Q16288 Show all » « Hide Q16288 [Direct mapping] NT-3 growth factor receptor Q96CY4 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 3 {ECO:0000313\|EMBL:AAH13693.1}; Neurotrophic tyrosine kinase, receptor, type 3, isoform CRA_e {ECO:0000313\|EMBL:EAX01993.1} R4GNH5 [Target identity:14%; Query identity:100%] NT-3 growth factor receptor {ECO:0000313\|Ensembl:ENSP00000473656} A9X3Y2 [Target identity:9%; Query identity:100%] Tyrosine kinase receptor isoform C {ECO:0000313\|EMBL:ABD27897.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000187 [activation of MAPK activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030335 [positive regulation of cell migration] GO:0032148 [activation of protein kinase B activity] GO:0032856 [activation of Ras GTPase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0050927 [positive regulation of positive chemotaxis] GO:2000251 [positive regulation of actin cytoskeleton reorganization]	612	68.5	Yes	1
NTRK3-003	ENSP00000437773 ENST00000542733	B7Z7U4 Show all » « Hide B7Z7U4 [Target identity:100%; Query identity:100%] Tyrosine-protein kinase receptor {ECO:0000256\|RuleBase:RU000312} R4GNH5 [Target identity:14%; Query identity:100%] NT-3 growth factor receptor {ECO:0000313\|Ensembl:ENSP00000473656}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0038179 [neurotrophin signaling pathway]	617	69	No	1
NTRK3-004	ENSP00000453959 ENST00000557856	Q16288 Show all » « Hide Q16288 [Direct mapping] NT-3 growth factor receptor X5DNW6 [Target identity:100%; Query identity:100%] Tyrosine-protein kinase receptor {ECO:0000256\|RuleBase:RU000312} X5DP84 [Target identity:63%; Query identity:100%] Neurotrophic tyrosine kinase receptor type 3 isoform A {ECO:0000313\|EMBL:AHW56691.1} R4GNH5 [Target identity:11%; Query identity:100%] NT-3 growth factor receptor {ECO:0000313\|Ensembl:ENSP00000473656} O95192 [Target identity:8%; Query identity:100%] Neurotrophin 3 receptor {ECO:0000313\|EMBL:AAC97478.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000187 [activation of MAPK activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030335 [positive regulation of cell migration] GO:0032148 [activation of protein kinase B activity] GO:0032856 [activation of Ras GTPase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0050927 [positive regulation of positive chemotaxis] GO:2000251 [positive regulation of actin cytoskeleton reorganization]	817	91.8	Yes	1
NTRK3-005	ENSP00000473656 ENST00000559188	R4GNH5 Show all » « Hide R4GNH5 [Target identity:100%; Query identity:100%] NT-3 growth factor receptor {ECO:0000313\|Ensembl:ENSP00000473656}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	90	10.7	No	0
NTRK3-007	ENSP00000473315 ENST00000558576		Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	146	16.2	No	0
NTRK3-010	ENSP00000473475 ENST00000560017	R4GN40 Show all » « Hide R4GN40 [Target identity:100%; Query identity:100%] NT-3 growth factor receptor {ECO:0000313\|Ensembl:ENSP00000473475}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		85	9.1	No	1
NTRK3-015	ENSP00000453511 ENST00000558676	H0YM90 Show all » « Hide H0YM90 [Target identity:100%; Query identity:100%] Tyrosine-protein kinase receptor {ECO:0000256\|RuleBase:RU000312} X5DP84 [Target identity:73%; Query identity:100%] Neurotrophic tyrosine kinase receptor type 3 isoform A {ECO:0000313\|EMBL:AHW56691.1} R4GNH5 [Target identity:12%; Query identity:100%] NT-3 growth factor receptor {ECO:0000313\|Ensembl:ENSP00000473656} O95192 [Target identity:9%; Query identity:100%] Neurotrophin 3 receptor {ECO:0000313\|EMBL:AAC97478.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0038179 [neurotrophin signaling pathway]	705	78.6	Yes	1
NTRK3-201	ENSP00000347397 ENST00000355254	Q16288 Show all » « Hide Q16288 [Direct mapping] NT-3 growth factor receptor X5DNW6 [Target identity:100%; Query identity:100%] Tyrosine-protein kinase receptor {ECO:0000256\|RuleBase:RU000312} X5DP84 [Target identity:63%; Query identity:100%] Neurotrophic tyrosine kinase receptor type 3 isoform A {ECO:0000313\|EMBL:AHW56691.1} R4GNH5 [Target identity:11%; Query identity:100%] NT-3 growth factor receptor {ECO:0000313\|Ensembl:ENSP00000473656} O95192 [Target identity:8%; Query identity:100%] Neurotrophin 3 receptor {ECO:0000313\|EMBL:AAC97478.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000187 [activation of MAPK activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030335 [positive regulation of cell migration] GO:0032148 [activation of protein kinase B activity] GO:0032856 [activation of Ras GTPase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0050927 [positive regulation of positive chemotaxis] GO:2000251 [positive regulation of actin cytoskeleton reorganization]	817	91.8	Yes	1
NTRK3-202	ENSP00000350356 ENST00000357724	Q16288 Show all » « Hide Q16288 [Direct mapping] NT-3 growth factor receptor X5DP84 [Target identity:62%; Query identity:100%] Neurotrophic tyrosine kinase receptor type 3 isoform A {ECO:0000313\|EMBL:AHW56691.1} R4GNH5 [Target identity:10%; Query identity:100%] NT-3 growth factor receptor {ECO:0000313\|Ensembl:ENSP00000473656} O95192 [Target identity:8%; Query identity:100%] Neurotrophin 3 receptor {ECO:0000313\|EMBL:AAC97478.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000187 [activation of MAPK activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030335 [positive regulation of cell migration] GO:0032148 [activation of protein kinase B activity] GO:0032856 [activation of Ras GTPase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0050927 [positive regulation of positive chemotaxis] GO:2000251 [positive regulation of actin cytoskeleton reorganization]	831	93.5	Yes	1
NTRK3-203	ENSP00000354207 ENST00000360948	Q16288 Show all » « Hide Q16288 [Direct mapping] NT-3 growth factor receptor X5D2R1 [Target identity:100%; Query identity:100%] Tyrosine-protein kinase receptor {ECO:0000256\|RuleBase:RU000312} R4GNH5 [Target identity:10%; Query identity:100%] NT-3 growth factor receptor {ECO:0000313\|Ensembl:ENSP00000473656}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000187 [activation of MAPK activity] GO:0001764 [neuron migration] GO:0001933 [negative regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007623 [circadian rhythm] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019056 [modulation by virus of host transcription] GO:0030335 [positive regulation of cell migration] GO:0032148 [activation of protein kinase B activity] GO:0032856 [activation of Ras GTPase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0042490 [mechanoreceptor differentiation] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0045471 [response to ethanol] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048665 [neuron fate specification] GO:0048678 [response to axon injury] GO:0048691 [positive regulation of axon extension involved in regeneration] GO:0048712 [negative regulation of astrocyte differentiation] GO:0050927 [positive regulation of positive chemotaxis] GO:0051412 [response to corticosterone] GO:0060548 [negative regulation of cell death] GO:0070306 [lens fiber cell differentiation] GO:0071300 [cellular response to retinoic acid] GO:0090102 [cochlea development] GO:2000251 [positive regulation of actin cytoskeleton reorganization]	839	94.4	Yes	1
NTRK3-204	ENSP00000444673 ENST00000540489	Q16288 Show all » « Hide Q16288 [Direct mapping] NT-3 growth factor receptor Q96CY4 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 3 {ECO:0000313\|EMBL:AAH13693.1}; Neurotrophic tyrosine kinase, receptor, type 3, isoform CRA_e {ECO:0000313\|EMBL:EAX01993.1} R4GNH5 [Target identity:14%; Query identity:100%] NT-3 growth factor receptor {ECO:0000313\|Ensembl:ENSP00000473656} A9X3Y2 [Target identity:9%; Query identity:100%] Tyrosine kinase receptor isoform C {ECO:0000313\|EMBL:ABD27897.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000187 [activation of MAPK activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030335 [positive regulation of cell migration] GO:0032148 [activation of protein kinase B activity] GO:0032856 [activation of Ras GTPase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0050927 [positive regulation of positive chemotaxis] GO:2000251 [positive regulation of actin cytoskeleton reorganization]	612	68.5	Yes	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx