PML

GENERAL INFORMATION

? »

Gene name

PML

Gene description

Promyelocytic leukemia

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

18
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in most cell types.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA008312 , CAB010194 , CAB016304
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

PML (HGNC Symbol)

Synonyms

MYL, RNF71, TRIM19

Description

Promyelocytic leukemia (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q24.1

Chromosome location (bp)

73994673 - 74047812

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140464 (version 78.38)

Entrez gene

5371

UniProt

P29590 (UniProt - Evidence at protein level)

neXtProt

NX_P29590

Antibodypedia

PML antibodies


PROTEIN BROWSER

? »
 
 
 « 
 
ENST00000268058
 
ENST00000268059
 
ENST00000354026
 
ENST00000359928
 
ENST00000395132
 
ENST00000395135
 
ENST00000435786
 
ENST00000436891
 
ENST00000562086
 
ENST00000563500
 
ENST00000564428
 
ENST00000565239
 
ENST00000565898
 
ENST00000566068
 
ENST00000567543
 
ENST00000567606
 
ENST00000569477
 
ENST00000569965
 
 » 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PML-001 ENSP00000268058
ENST00000268058
P29590
Show all »
Show » Show » 882 97.6 No 0
PML-002 ENSP00000378564
ENST00000395132
P29590
Show all »
Show » Show » 435 48.6 No 0
PML-003 ENSP00000268059
ENST00000268059
P29590
Show all »
Show » Show » 829 90.7 No 0
PML-004 ENSP00000315434
ENST00000354026
P29590
Show all »
Show » Show » 781 85.7 No 0
PML-005 ENSP00000455838
ENST00000565898
P29590
Show all »
Show » Show » 834 92.6 No 0
PML-006 ENSP00000378567
ENST00000395135
P29590
Show all »
Show » Show » 633 70 No 0
PML-007 ENSP00000455612
ENST00000569477
P29590
Show all »
Show » Show » 641 70.4 No 0
PML-008 ENSP00000456486
ENST00000569965
P29590
Show all »
Show » Show » 560 62 No 0
PML-009 ENSP00000456277
ENST00000567543
P29590
Show all »
Show » Show » 423 47.6 No 0
PML-010 ENSP00000395576
ENST00000435786
P29590
Show all »
Show » Show » 611 67.5 No 0
PML-011 ENSP00000394642
ENST00000436891
P29590
Show all »
Show » Show » 560 62 No 0
PML-012 ENSP00000457023
ENST00000564428
P29590
Show all »
Show » Show » 585 65 No 0
PML-013 ENSP00000353004
ENST00000359928
P29590
Show all »
Show » Show » 423 47.6 No 0
PML-015 ENSP00000457032
ENST00000563500
H3BT57
Show all »
Show » Show » 568 62.9 No 0
PML-017 ENSP00000457669
ENST00000567606
Q05835
Show all »
Show » 261 28.7 No 0
PML-018 ENSP00000456329
ENST00000562086
H3BRN3
Show all »
Show » 110 11.8 No 0
PML-022 ENSP00000456989
ENST00000565239
Q05835
Show all »
Show » 240 26.4 No 0
PML-023 ENSP00000458061
ENST00000566068
Q9UE85
Show all »
Show » 217 23 No 0