BCL2A1

GENE INFORMATION

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Gene name

BCL2A1 (HGNC Symbol)

Synonyms

ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1

Description

BCL2-related protein A1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q25.1

Chromosome location (bp)

79960889 - 79971446

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140379 (version 78.38)

Entrez gene

597

UniProt

Q16548 (UniProt - Evidence at protein level)

neXtProt

NX_Q16548

Antibodypedia

BCL2A1 antibodies
 

PROTEIN VIEW

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BCL2A1-001
 
BCL2A1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL2A1-001 ENSP00000267953
ENST00000267953
Q16548
Show all »
Show » Show » 175 20.1 No 0
BCL2A1-002 ENSP00000335250
ENST00000335661
Q16548
Show all »
Show » Show » 163 18.7 No 0