|
GENE INFORMATION
? »
|
The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version.
The Entrez gene identifier for the gene is also given. If any of the protein products of
the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the
neXtProt databases for these proteins are displayed.
There is also a link to the Antibodypedia portal where validation data for antibodies produced by other suppliers
against this gene can be found.
|
Gene name |
GCNT3 (HGNC Symbol) |
Synonyms |
C2/4GnT, C2GnT-M, C2GnT2 |
Description |
Glucosaminyl (N-acetyl) transferase 3, mucin type (HGNC Symbol) |
Entrez gene summary |
This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009] |
Chromosome |
15 |
Cytoband |
q22.2 |
Chromosome location (bp) |
59594875 - 59640239 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000140297 (version 78.38) |
Entrez gene |
9245 |
UniProt |
O95395 (UniProt - Evidence at transcript level) |
neXtProt |
NX_O95395 |
Antibodypedia |
GCNT3 antibodies |
|
|
|
PROTEIN VIEW
? »
|
The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues
(HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius
(turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed
( read more), and at the bottom of the protein view is the protein scale.
|
|
|
|
PROTEIN INFORMATION
? »
|
The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant.
The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors
SPOCTOPUS,
SignalP 4.0, and
Phobius) and the number of predicted transmembrane region(s) (according to
MDM) are also reported.
|
Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
|
GCNT3-001 |
ENSP00000379377
ENST00000396065
|
O95395 Show all »
« Hide
O95395 [Direct mapping]Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 A0A024R5T9 [Target identity:100%; Query identity:100%]Glucosaminyl (N-acetyl) transferase 3, mucin type, isoform CRA_a {ECO:0000313|EMBL:EAW77572.1} H0YMW7 [Target identity:34%; Query identity:100%]Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 {ECO:0000313|Ensembl:ENSP00000453774} H0YM40 [Target identity:19%; Query identity:100%]Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 {ECO:0000313|Ensembl:ENSP00000453453} H0YNA3 [Target identity:12%; Query identity:100%]Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 {ECO:0000313|Ensembl:ENSP00000453928}
|
Show »
« Hide
Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
GO:0000139 [Golgi membrane] GO:0002426 [immunoglobulin production in mucosal tissue] GO:0003829 [beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006493 [protein O-linked glycosylation] GO:0008109 [N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0047225 [acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity] GO:0048729 [tissue morphogenesis] GO:0050892 [intestinal absorption] GO:0060993 [kidney morphogenesis] GO:0070062 [extracellular vesicular exosome]
|
438 |
50.9 |
No |
1 |
GCNT3-005 |
ENSP00000453453
ENST00000559189
|
H0YM40 Show all »
« Hide
H0YM40 [Target identity:100%; Query identity:100%]Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 {ECO:0000313|Ensembl:ENSP00000453453} H0YNA3 [Target identity:60%; Query identity:100%]Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 {ECO:0000313|Ensembl:ENSP00000453928}
|
Show »
« Hide
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)
|
|
87 |
10 |
No |
1 |
GCNT3-007 |
ENSP00000453928
ENST00000559626
|
H0YNA3 Show all »
« Hide
H0YNA3 [Target identity:100%; Query identity:100%]Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 {ECO:0000313|Ensembl:ENSP00000453928}
|
Show »
« Hide
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)
|
|
53 |
6.3 |
No |
1 |
GCNT3-008 |
ENSP00000452741
ENST00000560585
|
O95395 Show all »
« Hide
O95395 [Direct mapping]Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 A0A024R5T9 [Target identity:100%; Query identity:100%]Glucosaminyl (N-acetyl) transferase 3, mucin type, isoform CRA_a {ECO:0000313|EMBL:EAW77572.1} H0YMW7 [Target identity:34%; Query identity:100%]Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 {ECO:0000313|Ensembl:ENSP00000453774} H0YM40 [Target identity:19%; Query identity:100%]Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 {ECO:0000313|Ensembl:ENSP00000453453} H0YNA3 [Target identity:12%; Query identity:100%]Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 {ECO:0000313|Ensembl:ENSP00000453928}
|
Show »
« Hide
Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
|
438 |
50.9 |
No |
1 |
GCNT3-010 |
ENSP00000453774
ENST00000559200
|
H0YMW7 Show all »
« Hide
H0YMW7 [Target identity:100%; Query identity:100%]Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 {ECO:0000313|Ensembl:ENSP00000453774} H0YM40 [Target identity:56%; Query identity:100%]Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 {ECO:0000313|Ensembl:ENSP00000453453} H0YNA3 [Target identity:34%; Query identity:100%]Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 {ECO:0000313|Ensembl:ENSP00000453928}
|
Show »
« Hide
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)
|
|
153 |
18 |
No |
1 |
|
|
|
|
|