FBLN5

GENE INFORMATION

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Gene name

FBLN5 (HGNC Symbol)

Synonyms

ARMD3, DANCE, EVEC, UP50

Description

Fibulin 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q32.12

Chromosome location (bp)

91869412 - 91947987

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140092 (version 78.38)

Entrez gene

10516

UniProt

Q9UBX5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UBX5

Antibodypedia

FBLN5 antibodies
 

PROTEIN VIEW

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FBLN5-001
 
FBLN5-002
 
FBLN5-003
 
FBLN5-005
 
FBLN5-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FBLN5-001 ENSP00000345008
ENST00000342058
Q9UBX5
Show all »
Show » Show » 448 50.2 Yes 0
FBLN5-002 ENSP00000267620
ENST00000267620
G3XA98
Show all »
Show » Show » 489 54.1 Yes 0
FBLN5-003 ENSP00000451982
ENST00000556154
G3V4U0
Show all »
Show » Show » 453 50.9 Yes 0
FBLN5-005 ENSP00000451486
ENST00000554468
G3V3Y2
Show all »
Show » Show » 91 9.9 Yes 0
FBLN5-009 ENSP00000450719
ENST00000554121
Show » 157 17.5 No 0