ESR2 - Gene info - The Human Protein Atlas

Gene name

ESR2 (HGNC Symbol)

Synonyms

Erb, NR3A2

Description

Estrogen receptor 2 (ER beta) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

Chromosome location (bp)

64084232 - 64338112

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140009 (version 78.38)

Entrez gene

2100

UniProt

Q92731 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ESR2-001

ENSP00000343925
ENST00000341099

Q92731
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Q92731 [Direct mapping]
Estrogen receptor beta
Q7LCB3 [Target identity:100%; Query identity:100%]
5p152 {ECO:0000313|EMBL:AAG29940.1}; Estrogen nuclear receptor beta variant a {ECO:0000313|EMBL:ADZ17331.1}; Estrogen receptor 2 (ER beta), isoform CRA_a {ECO:0000313|EMBL:EAW80845.1}; Estrogen receptor 2 isoform A {ECO:0000313|EMBL:AHW56473.1}
G3V5S2 [Target identity:88%; Query identity:100%]
Estrogen receptor beta {ECO:0000313|Ensembl:ENSP00000452485}

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Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001541 [ovarian follicle development]
GO:0001764 [neuron migration]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007420 [brain development]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008628 [hormone-mediated apoptotic signaling pathway]
GO:0010467 [gene expression]
GO:0019899 [enzyme binding]
GO:0030284 [estrogen receptor activity]
GO:0030308 [negative regulation of cell growth]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0034056 [estrogen response element binding]
GO:0042127 [regulation of cell proliferation]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0048019 [receptor antagonist activity]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060065 [uterus development]
GO:0060068 [vagina development]
GO:0060740 [prostate gland epithelium morphogenesis]
GO:0060743 [epithelial cell maturation involved in prostate gland development]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:1900116 [extracellular negative regulation of signal transduction]

530

59.2

ESR2-002

ENSP00000351412
ENST00000358599

Q92731
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Q92731 [Direct mapping]
Estrogen receptor beta
F1D8N3 [Target identity:100%; Query identity:100%]
Estrogen nuclear receptor beta variant b {ECO:0000313|EMBL:ADZ17332.1}; Estrogen receptor 2 (ER beta), isoform CRA_d {ECO:0000313|EMBL:EAW80851.1}
G3V5S2 [Target identity:94%; Query identity:100%]
Estrogen receptor beta {ECO:0000313|Ensembl:ENSP00000452485}

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0019899 [enzyme binding]
GO:0030284 [estrogen receptor activity]
GO:0030308 [negative regulation of cell growth]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0034056 [estrogen response element binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0048019 [receptor antagonist activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:1900116 [extracellular negative regulation of signal transduction]

495

55.5

ESR2-003

ENSP00000450699
ENST00000554572

Q92731
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495

55.5

ESR2-004

ENSP00000452485
ENST00000556275

G3V5S2
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G3V5S2 [Target identity:100%; Query identity:100%]
Estrogen receptor beta {ECO:0000313|Ensembl:ENSP00000452485}

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Predicted intracellular proteins

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GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]

468

52.5

ESR2-005

ENSP00000451582
ENST00000557772

Q92731
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Q92731 [Direct mapping]
Estrogen receptor beta
G3V5S2 [Target identity:99%; Query identity:100%]
Estrogen receptor beta {ECO:0000313|Ensembl:ENSP00000452485}

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472

ESR2-011

ENSP00000452426
ENST00000553796

Q92731
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Q92731 [Direct mapping]
Estrogen receptor beta
G3V5S2 [Target identity:98%; Query identity:100%]
Estrogen receptor beta {ECO:0000313|Ensembl:ENSP00000452485}

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474

53.2

ESR2-012

ENSP00000450488
ENST00000555278

Q92731
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Q92731 [Direct mapping]
Estrogen receptor beta
G3V5S2 [Target identity:97%; Query identity:100%]
Estrogen receptor beta {ECO:0000313|Ensembl:ENSP00000452485}

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481

54.1

ESR2-201

ENSP00000267525
ENST00000267525

Q92731
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Q92731 [Direct mapping]
Estrogen receptor beta

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0019899 [enzyme binding]
GO:0030284 [estrogen receptor activity]
GO:0030308 [negative regulation of cell growth]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0034056 [estrogen response element binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0048019 [receptor antagonist activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:1900116 [extracellular negative regulation of signal transduction]

439

48.6

ESR2-202

ENSP00000335551
ENST00000353772

Q92731
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495

55.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.