SSTR1

GENERAL INFORMATION

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Gene name

SSTR1

Gene description

Somatostatin receptor 1

Protein class

FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (stomach)
GTEx:Tissue enhanced (stomach)

Protein evidence

Evidence at protein level

Protein localization

Membranous and cytoplasmic expression in several tissues, most abundant in gastrointestinal tract.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA031506
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (stomach)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (stomach)

Organ

Expression



GENE INFORMATION

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Gene name

SSTR1

Synonyms

Description

Somatostatin receptor 1 (HGNC Symbol)

Entrez gene summary

Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

Chromosome

14

Cytoband

q21.1

Chromosome location (bp)

38207999 - 38213067

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000139874 (version 78.38)

Entrez gene

6751

UniProt

P30872 (UniProt - Evidence at protein level)

neXtProt

NX_P30872

Antibodypedia

SSTR1 antibodies


PROTEIN BROWSER

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ENST00000267377
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SSTR1-002 ENSP00000267377
ENST00000267377
P30872
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