RB1

GENE INFORMATION

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Gene name

RB1 (HGNC Symbol)

Synonyms

OSRC, PPP1R130, RB

Description

Retinoblastoma 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q14.2

Chromosome location (bp)

48303751 - 48481986

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000139687 (version 78.38)

Entrez gene

5925

UniProt

P06400 (UniProt - Evidence at protein level)

neXtProt

NX_P06400

Antibodypedia

RB1 antibodies
 

PROTEIN VIEW

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RB1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RB1-002 ENSP00000267163
ENST00000267163
P06400
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