IL21

GENE INFORMATION

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Gene name

IL21 (HGNC Symbol)

Synonyms

IL-21, Za11

Description

Interleukin 21 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Chromosome

4

Cytoband

q27

Chromosome location (bp)

122612628 - 122621069

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138684 (version 78.38)

Entrez gene

59067

UniProt

Q9HBE4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HBE4

Antibodypedia

IL21 antibodies
 

PROTEIN VIEW

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IL21-001
 
IL21-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL21-001 ENSP00000264497
ENST00000264497
Q9HBE4
Show all »
Show » Show » 162 18.7 Yes 0
IL21-201 ENSP00000477555
ENST00000611104
Q9HBE4
Show all »
Show » Show » 153 17.6 Yes 0