COPS4

GENE INFORMATION

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Gene name

COPS4 (HGNC Symbol)

Synonyms

CSN4

Description

COP9 signalosome subunit 4 (HGNC Symbol)

Entrez gene summary

This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

4

Cytoband

q21.22

Chromosome location (bp)

83034447 - 83075818

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138663 (version 78.38)

Entrez gene

51138

UniProt

Q9BT78 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BT78

Antibodypedia

COPS4 antibodies
 

PROTEIN VIEW

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COPS4-001
 
COPS4-002
 
COPS4-003
 
COPS4-004
 
COPS4-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COPS4-001 ENSP00000264389
ENST00000264389
Q9BT78
Show all »
Show » Show » 406 46.3 No 0
COPS4-002 ENSP00000425976
ENST00000509093
Q9BT78
Show all »
Show » Show » 352 40.2 No 0
COPS4-003 ENSP00000424791
ENST00000503682
D6RFN0
Show all »
Show » Show » 438 49.7 No 0
COPS4-004 ENSP00000424655
ENST00000511653
D6RAX7
Show all »
Show » Show » 420 47.7 No 0
COPS4-011 ENSP00000425486
ENST00000509317
D6RD63
Show all »
Show » Show » 275 31.4 No 0