STAT4

GENE INFORMATION

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Gene name

STAT4

Synonyms

Description

Signal transducer and activator of transcription 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

Chromosome

2

Cytoband

Chromosome location (bp)

191029576 - 191151596

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138378 (version 78.38)

Entrez gene

6775

UniProt

Q14765 (UniProt - Evidence at protein level)

neXtProt

NX_Q14765

Antibodypedia

STAT4 antibodies
 

PROTEIN VIEW

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STAT4-001
 
STAT4-002
 
STAT4-004
 
STAT4-005
 
STAT4-006
 
STAT4-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STAT4-001 ENSP00000351255
ENST00000358470
Q14765
Show all »
Show » Show » 748 85.9 No 0
STAT4-002 ENSP00000376134
ENST00000392320
Q14765
Show all »
Show » Show » 748 85.9 No 0
STAT4-004 ENSP00000412397
ENST00000450994
E9PBE2
Show all »
Show » Show » 79 9.5 No 0
STAT4-005 ENSP00000414322
ENST00000432798
C9JM11
Show all »
Show » Show » 25 3.1 No 0
STAT4-006 ENSP00000403238
ENST00000413064
C9JFG0
Show all »
Show » Show » 97 11.2 No 0
STAT4-007 ENSP00000386288
ENST00000409995
E9PG69
Show all »
Show » Show » 117 13.7 No 0