DNA2

GENE INFORMATION

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Gene name

DNA2 (HGNC Symbol)

Synonyms

DNA2L, KIAA0083

Description

DNA replication helicase/nuclease 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Chromosome

10

Cytoband

q21.3

Chromosome location (bp)

68414064 - 68472121

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138346 (version 78.38)

Entrez gene

1763

UniProt

P51530 (UniProt - Evidence at protein level)

neXtProt

NX_P51530

Antibodypedia

DNA2 antibodies
 

PROTEIN VIEW

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DNA2-001
 
DNA2-002
 
DNA2-005
 
DNA2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DNA2-001 ENSP00000351185
ENST00000358410
P51530
Show all »
Show » Show » 1060 120.4 No 0
DNA2-002 ENSP00000389713
ENST00000440722
Show » 375 42.2 No 0
DNA2-005 ENSP00000450393
ENST00000551118
F8VR31
Show all »
Show » 867 98.6 No 0
DNA2-201 ENSP00000382133
ENST00000399180
P51530
Show all »
Show » Show » 687 78.5 No 0